PMID- 7070957
OWN - NLM
STAT- MEDLINE
DCOM- 19820614
LR  - 20190726
IS  - 0031-6768 (Print)
IS  - 0031-6768 (Linking)
VI  - 392
IP  - 3
DP  - 1982 Jan
TI  - Response of ventilatory muscles of the rat to endurance training.
PG  - 268-71
AB  - The effect of endurance training on the oxidative and glycolytic potentials of 
      the diaphragm and intercostal muscles of rats has been studied. Training 
      consisted of treadmill running (28 m/min, 60 min/day, 5 days/wk) for periods 
      ranging from 8-26 weeks. Exercise of similar duration and intensity produced a 
      glycogen depletion in the diaphragm and intercostal muscles of nontrained rats. 
      Oxidative potential was estimated from the activity of the mitochondrial marker 
      enzyme succinate dehydrogenase (SDH). The activities of phosphorylase (PHOS), 
      hexokinase (HK), and lactate dehydrogenase (LDH) were determined as well as the 
      distribution of the LDH isozymes. SDH activity averaged 44 (42-51) and 17 
      (10-22)% (P less than 0.0l) greater in the plantaris and diaphragm muscles, 
      respectively, after 8-12 weeks of endurance running as compared to the sedentary 
      animals. There was no change in the SDH activity of the intercostal muscles or in 
      the activities of the glycolytic enzymes. There was also no change in the 
      distribution of the isozymes of LDH. Extending the duration of the training 
      program to 26 weeks did not produce any additional alteration in the magnitude of 
      the adaptation observed after the initial training period. Comparative studies of 
      different types of muscles demonstrated that the diaphragm, although having a 
      fiber composition somewhat similar to that of a fast-twitch skeletal muscle, has 
      a metabolic profile that is intermediate between pure slow twitch skeletal muscle 
      and cardiac muscle.
FAU - Moore, R L
AU  - Moore RL
FAU - Gollnick, P D
AU  - Gollnick PD
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pflugers Arch
JT  - Pflugers Archiv : European journal of physiology
JID - 0154720
RN  - 9005-79-2 (Glycogen)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Diaphragm/enzymology/*physiology
MH  - Female
MH  - Glycogen/metabolism
MH  - Intercostal Muscles/enzymology/*physiology
MH  - Mitochondria/enzymology
MH  - Oxidation-Reduction
MH  - *Physical Endurance
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Respiration
MH  - Succinate Dehydrogenase/metabolism
MH  - Time Factors
OID - NASA: 82174188
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1007/BF00584308 [doi]
PST - ppublish
SO  - Pflugers Arch. 1982 Jan;392(3):268-71. doi: 10.1007/BF00584308.