PMID- 7075146
OWN - NLM
STAT- MEDLINE
DCOM- 19820722
LR  - 20190821
IS  - 0143-5221 (Print)
IS  - 0143-5221 (Linking)
VI  - 62
IP  - 5
DP  - 1982 May
TI  - Erythrocyte metabolism in patients on haemodialysis and continuous ambulatory 
      peritoneal dialysis.
PG  - 479-88
AB  - 1. Erythrocyte metabolism was investigated and glycolytic intermediates were 
      measured in nine patients with chronic renal failure who were subsequently 
      treated with haemodialysis. The same investigations were performed in nine 
      patients on continuous ambulatory peritoneal dialysis (CAPD) who had previously 
      been treated with intermittent peritoneal dialysis (IPD) (eight patients) or 
      dietary restriction (one patient). 2. The patients who received haemodialysis had 
      a partially compensated metabolic acidosis before treatment. With haemodialysis, 
      plasma phosphate (Pi) fell and base excess, erythrocyte 2,3-diphosphoglycerate 
      (2,3-DPG), glucose consumption and lactate production rose significantly. In this 
      group the most important influence on erythrocyte metabolism was base excess. The 
      pattern of erythrocyte glycolytic intermediates showed that the rise in 2,3-DPG 
      with haemodialysis was brought about within the Rapoport-Luebering shunt; there 
      was no statistically significant decrease in haemoglobin-oxygen affinity. 3. The 
      patients who received CAPD were not acidotic before starting this form of 
      treatment. With CAPD, there was a significant increase in haemoglobin and fall in 
      plasma phosphate, erythrocyte 2,3-DPG and glucose consumption. The major factors 
      influencing erythrocyte metabolism in this group were plasma phosphate and 
      haemoglobin concentration. The fall in 2,3-DPG was produced by inhibition of 
      6-phosphofructokinase (EC 2.7.1.11); despite this fall, haemoglobin-oxygen 
      affinity was not affected.
FAU - Summerfield, G P
AU  - Summerfield GP
FAU - Bellingham, A J
AU  - Bellingham AJ
FAU - Manlove, L
AU  - Manlove L
FAU - Forbes, A M
AU  - Forbes AM
FAU - Goldsmith, H J
AU  - Goldsmith HJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Blood Glucose)
RN  - 0 (Diphosphoglyceric Acids)
RN  - 0 (Hemoglobins)
RN  - 0 (Lactates)
RN  - 138-81-8 (2,3-Diphosphoglycerate)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - 2,3-Diphosphoglycerate
MH  - Blood Glucose/metabolism
MH  - Diphosphoglyceric Acids/blood
MH  - Erythrocytes/*metabolism
MH  - Glycolysis
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Kidney Failure, Chronic/*blood/therapy
MH  - Lactates/biosynthesis
MH  - Lactic Acid
MH  - Peritoneal Dialysis, Continuous Ambulatory
MH  - *Renal Dialysis
EDAT- 1982/05/01 00:00
MHDA- 1982/05/01 00:01
CRDT- 1982/05/01 00:00
PHST- 1982/05/01 00:00 [pubmed]
PHST- 1982/05/01 00:01 [medline]
PHST- 1982/05/01 00:00 [entrez]
AID - 10.1042/cs0620479 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 1982 May;62(5):479-88. doi: 10.1042/cs0620479.