PMID- 7095653
OWN - NLM
STAT- MEDLINE
DCOM- 19820924
LR  - 20181130
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 79
IP  - 4
DP  - 1982 Apr
TI  - [Effects of tofisopam on gastric functions in rats (author's transl)].
PG  - 307-15
AB  - The effects of tofisopam on gastric functions were examined in rats. 
      Intracerebroventricular (i.c.v.) injection of tofisopam (50 ot 100 microgram) 
      increased both basal gastric acid output and mucosal blood flow (MBF) in rats 
      anesthetized with urethane, while intravenous injection of tofisopam (10 mg/kg) 
      did not change the basal gastric acid output. Ten micrograms of tofisopam, 
      i.c.v., a dose which did not show any effect on the basal gastric acid output, 
      significantly inhibited the decrease in gastric acid output induced by 
      noradrenaline (5 microgram, i.c.v.). Tofisopam (10 mg/kg, i.v. or 100 microgram, 
      i.c.v.) showed no effect on the increase in gastric acid output induced by 
      electrical stimulation of the lateral hypothalamic area (LHA). These results, 
      together with the previous findings, suggest the tofisopam (i.c.v.) acts on the 
      nucleus dorsalis n. vagi and/or LHA and competes with noradrenaline. The gastric 
      acid output was increased remarkably under water-immersion stress, and this 
      increase lasted during the stress-loading, but the MBF did not show a 
      corresponding increase. Pretreatment of rats with tofisopam (100 mg/kg, 
      intraduodenal) significantly increased the MBF and inhibited the ulcer formation 
      caused by the stress. From these results, tofisopam may restore the unbalance 
      between sympathetic and parasympathetic nervous tones induced by stress-loading.
FAU - Sato, M
AU  - Sato M
FAU - Kitagawa, H
AU  - Kitagawa H
FAU - Fujiwara, M
AU  - Fujiwara M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
RN  - 0 (Anti-Anxiety Agents)
RN  - 12794-10-4 (Benzodiazepines)
RN  - UZC80HAU42 (tofisopam)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - *Anti-Anxiety Agents
MH  - Benzodiazepines/administration & dosage/*pharmacology
MH  - Gastric Acid/*metabolism
MH  - Gastric Mucosa/*blood supply
MH  - Hypothalamus/physiology
MH  - Immersion
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Norepinephrine/antagonists & inhibitors
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Regional Blood Flow/drug effects
MH  - Stress, Physiological
MH  - Vagus Nerve/physiology
EDAT- 1982/04/01 00:00
MHDA- 1982/04/01 00:01
CRDT- 1982/04/01 00:00
PHST- 1982/04/01 00:00 [pubmed]
PHST- 1982/04/01 00:01 [medline]
PHST- 1982/04/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 1982 Apr;79(4):307-15.