PMID- 7096916
OWN - NLM
STAT- MEDLINE
DCOM- 19820910
LR  - 20181113
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 5
IP  - 1
DP  - 1982 Jan-Feb
TI  - Effect of dietary carbohydrates during hypocaloric treatment of obesity on 
      peripheral thyroid hormone metabolism.
PG  - 47-52
AB  - The effect of different hypocaloric carbohydrate (CHO) intakes was evaluated in 8 
      groups of obese patients in order to assess the role of the CHO and the other 
      dietary sources in modulating the peripheral thyroid hormone metabolism. These 
      changes were independent of those of bw. Serum T3 concentrations appear to be 
      more easily affected than those of reverse T3 by dietary manipulation and CHO 
      content of the diet. A fall in T3 levels during the entire period of study with 
      respect to the basal levels occurred only when the CHO of the diet was 120 g/day 
      or less, independent of caloric intake (360, 645 or 1200 calories). Moreover, 
      reverse T3 concentrations were found increased during the entire period of study 
      when total CHO were very low (40 to 50 g/day) while they demonstrated only a 
      transient increase when CHO were at least 105 g/day (with 645 or more total 
      calories). Indeed, our data indicate that a threshold may exist in dietary CHO, 
      independent of caloric intake, below which modifications occur in thyroid hormone 
      concentrations. From these results it appears that the CHO content of the diet is 
      more important than non-CHO sources in modulating peripheral thyroid hormone 
      metabolism and that the influence of total calories is perhaps as pronounced as 
      that of CHO when a "permissive" amount of CHO is ingested.
FAU - Pasquali, R
AU  - Pasquali R
FAU - Parenti, M
AU  - Parenti M
FAU - Mattioli, L
AU  - Mattioli L
FAU - Capelli, M
AU  - Capelli M
FAU - Cavazzini, G
AU  - Cavazzini G
FAU - Baraldi, G
AU  - Baraldi G
FAU - Sorrenti, G
AU  - Sorrenti G
FAU - De Benedettis, G
AU  - De Benedettis G
FAU - Biso, P
AU  - Biso P
FAU - Melchionda, N
AU  - Melchionda N
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - Adult
MH  - Dietary Carbohydrates/*pharmacology
MH  - Energy Intake
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*diet therapy/metabolism
MH  - Thyroid Hormones/*metabolism
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1007/BF03350482 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 1982 Jan-Feb;5(1):47-52. doi: 10.1007/BF03350482.