PMID- 7096998
OWN - NLM
STAT- MEDLINE
DCOM- 19820910
LR  - 20190516
IS  - 0022-1724 (Print)
IS  - 0022-1724 (Linking)
VI  - 89
IP  - 1
DP  - 1982 Aug
TI  - Evaluation of a human diploid cell strain rabies vaccine: final report of a three 
      year study of pre-exposure immunization.
PG  - 101-10
AB  - The antibody responses of 194 volunteers were studied for up to 3 years after 
      primary immunization with one, two or three doses of human diploid cell rabies 
      vaccine, administered either in 0.1 ml volumes intradermally (i.d.) or as 1.0 ml 
      intramuscularly (i.m.). Sero-conversion occurred in 95% of subjects after the 
      first injection and in 100% after the second. The highest titres and most durable 
      antibody responses were induced by three injections of vaccine. Booster doses 
      were administered either by the subcutaneous (s.c.) or i.d. route, after 6, 12 or 
      24 months to randomly grouped volunteers; these induced responses greater than or 
      equal to 5.0 i.u. per ml in 95% of subjects. The responses were rapid and were 
      neither influenced by the primary regimen nor by the timing and route of the 
      booster dose. Antibody titres after i.d. immunization were only two-fold lower 
      than those induced by the larger volume of vaccine. The findings suggest that the 
      i.d. route is both effective and economic.
FAU - Turner, G S
AU  - Turner GS
FAU - Nicholson, K G
AU  - Nicholson KG
FAU - Tyrrell, D A
AU  - Tyrrell DA
FAU - Aoki, F Y
AU  - Aoki FY
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hyg (Lond)
JT  - The Journal of hygiene
JID - 0375374
RN  - 0 (Antibodies, Viral)
RN  - 0 (Rabies Vaccines)
RN  - 0 (Vaccines, Attenuated)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/analysis
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunization, Secondary
MH  - Injections, Intradermal
MH  - Injections, Subcutaneous
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Rabies Vaccines/administration & dosage/*immunology
MH  - Rabies virus/immunology
MH  - Vaccines, Attenuated
PMC - PMC2134158
EDAT- 1982/08/01 00:00
MHDA- 1982/08/01 00:01
PMCR- 1982/08/01
CRDT- 1982/08/01 00:00
PHST- 1982/08/01 00:00 [pubmed]
PHST- 1982/08/01 00:01 [medline]
PHST- 1982/08/01 00:00 [entrez]
PHST- 1982/08/01 00:00 [pmc-release]
AID - 10.1017/s0022172400070583 [doi]
PST - ppublish
SO  - J Hyg (Lond). 1982 Aug;89(1):101-10. doi: 10.1017/s0022172400070583.