PMID- 7110523
OWN - NLM
STAT- MEDLINE
DCOM- 19821029
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 35
IP  - 1
DP  - 1982
TI  - Influence of brain histaminergic system on episodic growth hormone secretion in 
      the rat.
PG  - 43-7
AB  - The effects of histamine and amodiaquine (a drug known to inhibit 
      histamine-N-methyltransferase) on pulsatile growth hormone (GH) secretion were 
      determined in unanaesthetized male rats. Intracerebroventricular (i.c.v.) 
      administration of histamine (0.01, 0.05, 0.1 mumol/rat) caused a dose-related 
      suppression of spontaneous pulses of rat GH (rGH) secretion. Amodiaquine (0.16 
      mumol/rat i.c.v.) also inhibited the pulses, but to a lesser degree. The results, 
      which show the inhibitory effects of both exogenous histamine and increased 
      levels of endogenous histamine on pulsatile rGH secretion, support the hypothesis 
      that the histaminergic system also plays a role in physiological CNS control of 
      rGH secretion.
FAU - Netti, C
AU  - Netti C
FAU - Guidobono, F
AU  - Guidobono F
FAU - Olgiati, V R
AU  - Olgiati VR
FAU - Sibilia, V
AU  - Sibilia V
FAU - Pagani, F
AU  - Pagani F
FAU - Pecile, A
AU  - Pecile A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Receptors, Histamine)
RN  - 220236ED28 (Amodiaquine)
RN  - 820484N8I3 (Histamine)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Amodiaquine/pharmacology
MH  - Animals
MH  - Brain/*physiology
MH  - Growth Hormone/*metabolism
MH  - Histamine/pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Histamine/*physiology
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1159/000123353 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1982;35(1):43-7. doi: 10.1159/000123353.