PMID- 7114979
OWN - NLM
STAT- MEDLINE
DCOM- 19821021
LR  - 20211203
IS  - 0003-9926 (Print)
IS  - 0003-9926 (Linking)
VI  - 142
IP  - 9
DP  - 1982 Sep
TI  - Overt iron deficiency in sickle cell disease.
PG  - 1621-4
AB  - Overt iron deficiency was diagnosed in four patients with sickle cell disease. 
      Three patients had homozygous SS and one had hemoglobin SC disease. The cause in 
      each case was proved or suspected blood loss. Iron repletion was accompanied by 
      increases in the blood hemoglobin and hematocrit levels, erythrocyte mean 
      corpuscular volume, and mean corpuscular hemoglobin concentration (MCHC) and by 
      change in the RBC morphologic characteristics from hypochromic microcytic to 
      normochromic normocytic. The diagnosis of iron deficiency was confirmed by the 
      finding of a low serum ferritin level, a high serum total iron-binding capacity, 
      or both. Two patients who had had no painful crises while they were iron 
      deficient began having crises again, and another patient had painful crises for 
      the first time after the blood values improved. Whether a lowered MCHC is 
      beneficial to patients with sickle cell diseases is an important but unanswered 
      question.
FAU - Haddy, T B
AU  - Haddy TB
FAU - Castro, O
AU  - Castro O
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
RN  - 0 (Hemoglobins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Anemia, Hypochromic/blood/drug therapy/*etiology
MH  - Anemia, Sickle Cell/blood/*complications
MH  - Child
MH  - Erythrocyte Count
MH  - Erythrocyte Indices
MH  - Female
MH  - Hematocrit
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Iron/therapeutic use
MH  - Iron Deficiencies
MH  - Male
MH  - Middle Aged
EDAT- 1982/09/01 00:00
MHDA- 1982/09/01 00:01
CRDT- 1982/09/01 00:00
PHST- 1982/09/01 00:00 [pubmed]
PHST- 1982/09/01 00:01 [medline]
PHST- 1982/09/01 00:00 [entrez]
PST - ppublish
SO  - Arch Intern Med. 1982 Sep;142(9):1621-4.