PMID- 7118252
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 37
IP  - 2
DP  - 1982 Aug
TI  - Specificity of immunoglobulin E in coccidioidomycosis and correlation with 
      disease involvement.
PG  - 609-16
AB  - Serum immunoglobulin E (IgE) antibodies were quantitated in 26 patients with 
      active pulmonary coccidioidomycosis, 59 patients with active disseminated 
      disease, 12 patients in clinical remission, and 91 healthy subjects. Significant 
      differences were obtained in IgE serum levels of patients with active disease 
      versus healthy subjects (P less than 0.0001). Patients with pulmonary 
      coccidioidomycosis did not differ in their IgE levels when compared with patients 
      with disseminated disease. However, serum IgE levels were significantly increased 
      in patients with disease involving two or more organ systems when compared with 
      patients with pulmonary disease or extrapulmonary disease involving a single 
      organ system (P less than 0.02). Total serum IgE correlated with 
      anti-Coccidioides IgE (P less than 0.001), but with only six exceptions, patients 
      with anti-Coccidioides IgE also exhibited IgE antibodies to 1 or more of 12 
      common allergens. The correlation between hyperproduction of IgE and disease 
      severity coupled with the depressed cell-mediated immune status of patients with 
      this disease suggests a defect(s) in the T-lymphocyte population which functions 
      to regulate IgE synthesis.
FAU - Cox, R A
AU  - Cox RA
FAU - Baker, B S
AU  - Baker BS
FAU - Stevens, D A
AU  - Stevens DA
LA  - eng
GR  - AI-16095/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Allergens)
RN  - 0 (Antibodies, Fungal)
RN  - 12622-73-0 (Coccidioidin)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Antibodies, Fungal/biosynthesis
MH  - *Antibody Specificity
MH  - Bone Diseases/etiology/immunology
MH  - Coccidioidin/administration & dosage/immunology
MH  - Coccidioidomycosis/complications/diagnosis/*immunology
MH  - Dermatomycoses/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Joint Diseases/etiology/immunology
MH  - Longitudinal Studies
MH  - Lung Diseases, Fungal/immunology
MH  - Lymphatic Diseases/etiology/immunology
MH  - Male
MH  - Meningitis/etiology/immunology
MH  - Poaceae/immunology
MH  - Skin Tests
PMC - PMC347576
EDAT- 1982/08/01 00:00
MHDA- 1982/08/01 00:01
PMCR- 1982/08/01
CRDT- 1982/08/01 00:00
PHST- 1982/08/01 00:00 [pubmed]
PHST- 1982/08/01 00:01 [medline]
PHST- 1982/08/01 00:00 [entrez]
PHST- 1982/08/01 00:00 [pmc-release]
AID - 10.1128/iai.37.2.609-616.1982 [doi]
PST - ppublish
SO  - Infect Immun. 1982 Aug;37(2):609-16. doi: 10.1128/iai.37.2.609-616.1982.