PMID- 7119636
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20190904
IS  - 0022-0736 (Print)
IS  - 0022-0736 (Linking)
VI  - 15
IP  - 3
DP  - 1982
TI  - The meaning of bites on the vectorcardiogram: study in adriamycin cardiomyopathy.
PG  - 265-70
AB  - We examined 106 VCGs of cancer patients receiving Adriamycin (ADM) to investigate 
      the nature and meaning of bites. It is known that ADM causes patchy areas of 
      myocardial degeneration and necrosis, the appearance of which is dose dependent. 
      Thirty-eight cancer patients not yet receiving ADM were examined to provide 
      controls. Patients were divided into six groups, according to total cumulative 
      ADM dose received. The incidence of bites in the different groups was shown to be 
      as follows: group 1 (controls, 38 patients) 13.1%; group 2 (1-100 mg/m2 of body 
      surface ADM, 23 patients) 39.1%; group 3 (101-200 mg/m2, 33 patients) 42.2%; 
      group 4 (201-300 mg/m2, 25 patients) 56%; group 5 (301-400 mg/m2, 15 patients) 
      66.6%; group 6 (greater than 400 mg/m2, 10 patients) 90%; groups 2-6 52.8%. These 
      percentages show a trend which is highly correlated with the total cumulative 
      dose of ADM (p=0.00005). The influence of age on the appearance of bites has been 
      excluded by analyses of trends in patients below and over 50 years (p=0.08). In 
      80.35% of cases, bites appear on more than one plane and mostly close to the 
      maximum vector (Vmax). We therefore think that these results favor the hypothesis 
      that bites are the electrophysiologic expression of lesions, such as small 
      fibrotic and necrotic areas, which interfere with the normal spread of the 
      ventricular depolarization wavefront.
FAU - Vitolo, E
AU  - Vitolo E
FAU - Madoi, S
AU  - Madoi S
FAU - Colli, A M
AU  - Colli AM
FAU - Roveda, M
AU  - Roveda M
FAU - La Rovere, M T
AU  - La Rovere MT
FAU - Obbiassi, M
AU  - Obbiassi M
FAU - Labianca, R
AU  - Labianca R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiomyopathies/chemically induced/*diagnosis
MH  - Child
MH  - Dose-Response Relationship, Drug
MH  - Doxorubicin/*adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/drug therapy
MH  - *Vectorcardiography
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1016/s0022-0736(82)80028-9 [doi]
PST - ppublish
SO  - J Electrocardiol. 1982;15(3):265-70. doi: 10.1016/s0022-0736(82)80028-9.