PMID- 7120289
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20190709
IS  - 0022-2623 (Print)
IS  - 0022-2623 (Linking)
VI  - 25
IP  - 8
DP  - 1982 Aug
TI  - Brain levels and metabolism of the dopaminergic agonist 
      2-amino-6,7-dihydroxytetrahydronaphthalene after administration of various 
      prodrugs.
PG  - 993-6
AB  - The synthesis of four prodrug diesters (diacetyl, diisobutyryl, dipivaloyl, and 
      dibenzoyl) of the potent dopaminergic agonist 
      2-amino-6,7-dihydroxytetrahydronaphthalene (6,7-ADTN) is described. The effects 
      of prodrug structure on the levels of 6,7-ADTN in the rat corpus striatum and 
      cerebellum, as well as the levels of the metabolite, 
      6-hydroxy-7-methoxy-2-aminotetralin, in the corpus striatum, have been determined 
      after intraperitoneal administration. In addition, the striatal levels of 
      6,7-ADTN after administration of the dibenzoyl analogue via intraperitoneal, 
      subcutaneous, and oral routes have been measured. These prodrugs produce a 
      significant improvement in the penetration and accumulation of 6,7-ADTN in the 
      brain.
FAU - Horn, A S
AU  - Horn AS
FAU - Griever-Kazemier, H
AU  - Griever-Kazemier H
FAU - Dijkstra, D
AU  - Dijkstra D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Naphthalenes)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 53463-78-8 (ADTN)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Cerebellum/metabolism
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Corpus Striatum/metabolism
MH  - Drug Stability
MH  - Female
MH  - Naphthalenes/*administration & dosage/*chemical synthesis
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tetrahydronaphthalenes/*administration & dosage/*chemical synthesis/metabolism
MH  - Time Factors
EDAT- 1982/08/01 00:00
MHDA- 1982/08/01 00:01
CRDT- 1982/08/01 00:00
PHST- 1982/08/01 00:00 [pubmed]
PHST- 1982/08/01 00:01 [medline]
PHST- 1982/08/01 00:00 [entrez]
AID - 10.1021/jm00350a022 [doi]
PST - ppublish
SO  - J Med Chem. 1982 Aug;25(8):993-6. doi: 10.1021/jm00350a022.