PMID- 7120515
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20121115
IS  - 0098-4108 (Print)
IS  - 0098-4108 (Linking)
VI  - 9
IP  - 5-6
DP  - 1982 May-Jun
TI  - Distribution and metabolism of 2,4-dichlorophenol in rats.
PG  - 889-97
AB  - The metabolism and distribution of 2,4-dichlorophenol (2,4-DCP) were studied in 
      the rat after intravenous administration of 10 mg/kg. 2,4-DCP was determined by 
      gas chromatography with an electron-capture detector. The highest concentration 
      of 2,4-DCP was found in kidney, followed by liver, fat, and brain. 2,4-DCP is 
      metabolized to glucuronide and other conjugates. The parent compound and its 
      conjugates were rapidly eliminated from the body. The half-lives of 2,4-DCP and 
      its conjugates in plasma, fat, brain, liver, and kidney ranged from 4 to 30 min. 
      The volume of distribution of 2,4-DCP in plasma was 3.7 l/kg. Tissue/plasma 
      ratios indicated that 2,4-DCP has a greater affinity for kidney.
FAU - Somani, S M
AU  - Somani SM
FAU - Khalique, A
AU  - Khalique A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Toxicol Environ Health
JT  - Journal of toxicology and environmental health
JID - 7513622
RN  - 0 (Chlorophenols)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Animals
MH  - Chlorophenols/*metabolism
MH  - Chromatography, Gas
MH  - Injections, Intravenous
MH  - Kinetics
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1982/05/01 00:00
MHDA- 1982/05/01 00:01
CRDT- 1982/05/01 00:00
PHST- 1982/05/01 00:00 [pubmed]
PHST- 1982/05/01 00:01 [medline]
PHST- 1982/05/01 00:00 [entrez]
AID - 10.1080/15287398209530211 [doi]
PST - ppublish
SO  - J Toxicol Environ Health. 1982 May-Jun;9(5-6):889-97. doi: 
      10.1080/15287398209530211.