PMID- 7124564
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20131121
IS  - 0300-8924 (Print)
IS  - 0300-8924 (Linking)
VI  - 4
IP  - 1-2
DP  - 1982
TI  - Effects of ascorbic acid on neutrophil function. Studies on normal and chronic 
      granulomatous disease neutrophils.
PG  - 163-8
AB  - Ascorbic acid is able to stimulate neutrophil oxidative metabolism in normal 
      neutrophils, as well as other several functions of these cells, either in the 
      normal state or in the defective one. In the present study, we have investigated 
      the effects of ascorbic acid on the hexose monophosphate shunt (HMPS) and on the 
      bactericidal activity of neutrophils from Chronic Granulomatous Disease (CGD) 
      patients. Furthermore, we have investigated the effects of ascorbic acid on the 
      antibody dependent cell cytotoxicity (ADCC) of normal neutrophils. Ascorbic acid 
      in vitro was able to significantly improve both HMPS activity and bacterial 
      killing of CGD neutrophils. Its prolonged administration to such patients led to 
      consistent clinical improvement, possibly related to the enhancement of 
      chemotaxis, although the effects on HMPS and bacterial killing seen in vitro 
      could not be confirmed. Ascorbic acid was also able to interfere with neutrophil 
      ADCC with different results depending on its concentration and the experimental 
      conditions.
FAU - Patrone, F
AU  - Patrone F
FAU - Dallegri, F
AU  - Dallegri F
FAU - Bonvini, E
AU  - Bonvini E
FAU - Minervini, F
AU  - Minervini F
FAU - Sacchetti, C
AU  - Sacchetti C
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Acta Vitaminol Enzymol
JT  - Acta vitaminologica et enzymologica
JID - 0135063
RN  - 0 (Hexosephosphates)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Antibody-Dependent Cell Cytotoxicity/drug effects
MH  - Ascorbic Acid/*pharmacology/therapeutic use
MH  - Blood Bactericidal Activity/drug effects
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Granulomatous Disease, Chronic/drug therapy/*immunology
MH  - Hexosephosphates/blood
MH  - Humans
MH  - Neutrophils/*immunology/metabolism
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
PST - ppublish
SO  - Acta Vitaminol Enzymol. 1982;4(1-2):163-8.