PMID- 7142116 OWN - NLM STAT- MEDLINE DCOM- 19830119 LR - 20190512 IS - 0021-924X (Print) IS - 0021-924X (Linking) VI - 92 IP - 3 DP - 1982 Sep TI - Synthesis and secretion of plasma proteins by isolated hepatocytes of analbuminemic rats. PG - 775-9 AB - The synthesis and secretion of plasma proteins by isolated hepatocytes from the liver of Nagase analbuminemia rats (NAR) were investigated. NAR hepatocytes did not synthesize any albumin, but showed enhanced synthesis and secretion of several other plasma proteins, including transferrin, hemopexin, ceruloplasmin and fibrinogen. The lag period before the secretion of transferrin in NAR hepatocytes decreased. These findings indicate that the increased concentration of plasma globulins in NAR may be due to their enhanced synthesis and secretion in the liver. FAU - Sugiyama, K AU - Sugiyama K FAU - Emori, T AU - Emori T FAU - Nagase, S AU - Nagase S LA - eng PT - Journal Article PL - England TA - J Biochem JT - Journal of biochemistry JID - 0376600 RN - 0 (Blood Proteins) RN - 0 (Serum Albumin) SB - IM MH - Animals MH - Blood Proteins/biosynthesis/immunology/*metabolism MH - Cells, Cultured MH - Kinetics MH - Liver/*metabolism MH - Male MH - Rats MH - Rats, Inbred Strains MH - Serum Albumin/*deficiency EDAT- 1982/09/01 00:00 MHDA- 1982/09/01 00:01 CRDT- 1982/09/01 00:00 PHST- 1982/09/01 00:00 [pubmed] PHST- 1982/09/01 00:01 [medline] PHST- 1982/09/01 00:00 [entrez] AID - 10.1093/oxfordjournals.jbchem.a133989 [doi] PST - ppublish SO - J Biochem. 1982 Sep;92(3):775-9. doi: 10.1093/oxfordjournals.jbchem.a133989.