PMID- 7151862
OWN - NLM
STAT- MEDLINE
DCOM- 19830311
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 85
IP  - 1
DP  - 1982 Nov 5
TI  - Interactions between serotonergic and enkephalinergic neurons in rat striatum and 
      hypothalamus.
PG  - 29-34
AB  - We report evidence for an interaction between serotonergic and enkephalinergic 
      neurons in rat striatum and hypothalamus. The administration of drugs such as 
      p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine 
      that lower the striatal and hypothalamic serotonin (5-HT) content caused an 
      increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain 
      areas. Moreover, chronic treatment with PCPA induced an increase in the number of 
      striatal [3H][D]Ala2,Met5]enkephalinamide binding sites. These observations 
      suggest that serotonergic neurons modulate the functional activity of 
      enkephalinergic neurons in the rat striatum and hypothalamus. The significance of 
      this interaction is discussed.
FAU - Dellavedova, L
AU  - Dellavedova L
FAU - Parenti, M
AU  - Parenti M
FAU - Tirone, F
AU  - Tirone F
FAU - Groppetti, A
AU  - Groppetti A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Enkephalins)
RN  - 333DO1RDJY (Serotonin)
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Corpus Striatum/*metabolism
MH  - Dopamine/metabolism
MH  - Enkephalin, Methionine/metabolism
MH  - Enkephalins/*physiology
MH  - Hypothalamus/*metabolism
MH  - Kinetics
MH  - Male
MH  - Neurons/drug effects/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*physiology
EDAT- 1982/11/05 00:00
MHDA- 1982/11/05 00:01
CRDT- 1982/11/05 00:00
PHST- 1982/11/05 00:00 [pubmed]
PHST- 1982/11/05 00:01 [medline]
PHST- 1982/11/05 00:00 [entrez]
AID - 0014-2999(82)90421-6 [pii]
AID - 10.1016/0014-2999(82)90421-6 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1982 Nov 5;85(1):29-34. doi: 10.1016/0014-2999(82)90421-6.