PMID- 7156223
OWN - NLM
STAT- MEDLINE
DCOM- 19830311
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 29
IP  - 5
DP  - 1982 Nov
TI  - Central, as well as peripheral naloxone administration suppresses feeding in 
      food-deprived Sprague-Dawley and genetically obese (Zucker) rats.
PG  - 841-6
AB  - Food intake over 90 min post-injection was studied in groups of food deprived (20 
      hr) female Sprague-Dawley (S.D.) rats, fatty Zucker (fa/fa) rats and their 
      heterozygous lean litter mates (Fa/fa) of various ages, that bar-pressed for food 
      pellets on a FR-1 schedule following a subcutaneous (SC) or an 
      intracerebroventricular (IVT) injection of sterile saline or naloxone HCl. 
      Subcutaneous injections of naloxone HCl (10 mg/kg) reduced feeding in all three 
      groups of rats compared to SC saline; in addition, a greater percentage reduction 
      in food intake over the whole 90 min test period occurred in the fa/fa rats given 
      SC naloxone compared to the Fa/fa group. Intracerebroventricular naloxone (50 
      micrograms) decreased feeding over the initial 30 min period in the S.D. and 
      Fa/fa rats but a 100 micrograms IVT dose was needed to reduce feeding in the 
      fa/fa group. The results demonstrate that central naloxone administration can 
      suppress feeding in both non-obese and obese strains of rats as it is known to do 
      when given peripherally. These findings add yet further evidence to the premise 
      that endogenous opioid peptides may play an intricate and important physiological 
      role in the regulation of feeding behavior.
FAU - Thornhill, J A
AU  - Thornhill JA
FAU - Taylor, B
AU  - Taylor B
FAU - Marshall, W
AU  - Marshall W
FAU - Parent, K
AU  - Parent K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 36B82AMQ7N (Naloxone)
SB  - IM
MH  - Animals
MH  - Body Weight/*drug effects
MH  - Eating/*drug effects
MH  - Female
MH  - Food Deprivation
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Naloxone/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Zucker
EDAT- 1982/11/01 00:00
MHDA- 1982/11/01 00:01
CRDT- 1982/11/01 00:00
PHST- 1982/11/01 00:00 [pubmed]
PHST- 1982/11/01 00:01 [medline]
PHST- 1982/11/01 00:00 [entrez]
AID - 0031-9384(82)90334-1 [pii]
AID - 10.1016/0031-9384(82)90334-1 [doi]
PST - ppublish
SO  - Physiol Behav. 1982 Nov;29(5):841-6. doi: 10.1016/0031-9384(82)90334-1.