PMID- 7158294
OWN - NLM
STAT- MEDLINE
DCOM- 19830311
LR  - 20190821
IS  - 0001-5180 (Print)
IS  - 0001-5180 (Linking)
VI  - 114
IP  - 4
DP  - 1982
TI  - Morphological alterations in the medial preoptic area after prenatal 
      administration of phenobarbital.
PG  - 347-54
AB  - Pregnant Sabra mice received 3 g phenobarbital per kilogram milled food from 
      gestational days (GD) 9 to 18 as their only food source; control females received 
      milled food. All the females were divided into three groups and injected 
      intraperitoneally with a single dose of 3H-thymidine on GD 13, 15 or 17. At 50 
      days of age of the offspring were perfused with 10% neutral formalin and their 
      brains removed and prepared for autoradiography. Matching sagittal sections of 
      the offspring were selected for the study of the medial preoptic area (MPOA) of 
      the hypothalamus. The total number of cells per section was not significantly 
      different between males and females, however, there was a greater cellular 
      packing density (cell/mm2) in females (p less than 0.05). This sex difference 
      disappeared in treated offspring, possibly due to a 76% decrease on GD 13 in the 
      rate of cell proliferation in females (number of labeled cells but not in males 
      (p less than 0.001); the greatest decrease in the number of labeled cells 
      occurred in the sexually dimorphic areas of the MPOA (p less than 0.001). The 
      area of the sagittal section of the MPOA did not differ significantly between 
      sexes or treatments.
FAU - Yanai, J
AU  - Yanai J
FAU - Woolf, M
AU  - Woolf M
FAU - Feigenbaum, J J
AU  - Feigenbaum JJ
LA  - eng
GR  - DA2365/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Acta Anat (Basel)
JT  - Acta anatomica
JID - 0370272
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Animals
MH  - Brain/anatomy & histology
MH  - Female
MH  - Male
MH  - Mice/*embryology
MH  - Mice, Inbred Strains
MH  - Organ Size/drug effects
MH  - Phenobarbital/administration & dosage/*adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Preoptic Area/cytology/*drug effects/embryology
MH  - Sex Factors
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1159/000145607 [doi]
PST - ppublish
SO  - Acta Anat (Basel). 1982;114(4):347-54. doi: 10.1159/000145607.