PMID- 7159469
OWN - NLM
STAT- MEDLINE
DCOM- 19830311
LR  - 20190623
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 31
IP  - 23
DP  - 1982 Dec 1
TI  - Studies on the relation of gamma-hydroxybutyric acid (GHB) to gamma-aminobutyric 
      acid (GABA). Evidence that GABA is not the sole source for GHB in rat brain.
PG  - 3917-23
AB  - The effects of gamma-aminobutyric acid (GABA)-alpha-oxoglutarate aminotransferase 
      (GABA-T) inhibitors, L-glutamic acid decarboxylase (GAD) inhibitors, and 
      antipetit mal anticonvulsants on gamma-hydroxybutyric acid (GHB) and GABA were 
      studied. Treatment with anticonvulsants and GABA-T inhibitors resulted in an 
      increase in steady-state brain levels of both GHB and GABA. GAD inhibitors 
      produced markedly decreased levels of brain GABA but no change in GHB 
      concentrations. Studies of GHB derived exclusively from GABA showed that GABA-T 
      inhibitors which produced an elevation of steady-state levels of GHB in brain 
      also resulted in a decrease in GABA-derived GHB. Intracerebroventricular (i.c.v.) 
      administration of GABA, putrescine, and 1,4-butanediol all produced significant 
      elevations in brain GHB, but GABA-T inhibitors blocked this effect of GABA and 
      putrescine. These data suggest that there may be another source for GHB in brain 
      in addition to GABA and raise the possibility that 1,4-butanediol may be that 
      source.
FAU - Snead, O C 3rd
AU  - Snead OC 3rd
FAU - Liu, C C
AU  - Liu CC
FAU - Bearden, L J
AU  - Bearden LJ
LA  - eng
GR  - K07 NS 00484-02/NS/NINDS NIH HHS/United States
GR  - R01 NS 17117-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Hydroxybutyrates)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 7G33012534 (Sodium Oxybate)
RN  - EC 2.6.1.19 (4-Aminobutyrate Transaminase)
RN  - V10TVZ52E4 (Putrescine)
SB  - IM
MH  - 4-Aminobutyrate Transaminase/metabolism
MH  - Animals
MH  - Biotransformation
MH  - Brain/*metabolism
MH  - Cerebellum/metabolism
MH  - Hydroxybutyrates/*biosynthesis
MH  - Male
MH  - Putrescine/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sodium Oxybate/*biosynthesis
MH  - gamma-Aminobutyric Acid/*metabolism
EDAT- 1982/12/01 00:00
MHDA- 1982/12/01 00:01
CRDT- 1982/12/01 00:00
PHST- 1982/12/01 00:00 [pubmed]
PHST- 1982/12/01 00:01 [medline]
PHST- 1982/12/01 00:00 [entrez]
AID - 0006-2952(82)90310-0 [pii]
AID - 10.1016/0006-2952(82)90310-0 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 1982 Dec 1;31(23):3917-23. doi: 10.1016/0006-2952(82)90310-0.