PMID- 7174796
OWN - NLM
STAT- MEDLINE
DCOM- 19830214
LR  - 20190606
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 70
IP  - 6
DP  - 1982 Dec
TI  - SC erythrocytes have an abnormally high intracellular hemoglobin concentration. 
      Pathophysiological consequences.
PG  - 1315-9
AB  - We have examined 20 SC patients on Percoll-Stractan continuous density gradients 
      and find that they have an elevated mean corpuscular hemoglobin concentration 
      (MCHC). Reduction of the MCHC to normal values results in amelioration of four 
      physiologically important blood abnormalities: decreased oxygen affinity, 
      viscosity of deoxygenated erythrocyte suspensions, rate of sickling, and 
      deoxygenation induced K+ efflux. These observations suggest that the rehydration 
      of SC cells to normal values should be considered a potential approach in the 
      therapeutic manipulation of this disease.
FAU - Fabry, M E
AU  - Fabry ME
FAU - Kaul, D K
AU  - Kaul DK
FAU - Raventos-Suarez, C
AU  - Raventos-Suarez C
FAU - Chang, H
AU  - Chang H
FAU - Nagel, R L
AU  - Nagel RL
LA  - eng
GR  - HL21016/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Gels)
RN  - 0 (Hemoglobin, Sickle)
RN  - 9008-00-8 (Hemoglobin C)
RN  - RWP5GA015D (Potassium)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Anemia, Sickle Cell/*blood
MH  - Erythrocytes, Abnormal/*physiology
MH  - Gels
MH  - Hemoglobin C/*metabolism
MH  - Hemoglobin, Sickle/*metabolism
MH  - Humans
MH  - Osmolar Concentration
MH  - Oxygen/blood
MH  - Potassium/blood
MH  - Solubility
PMC - PMC370350
EDAT- 1982/12/01 00:00
MHDA- 1982/12/01 00:01
PMCR- 1982/12/01
CRDT- 1982/12/01 00:00
PHST- 1982/12/01 00:00 [pubmed]
PHST- 1982/12/01 00:01 [medline]
PHST- 1982/12/01 00:00 [entrez]
PHST- 1982/12/01 00:00 [pmc-release]
AID - 10.1172/jci110732 [doi]
PST - ppublish
SO  - J Clin Invest. 1982 Dec;70(6):1315-9. doi: 10.1172/jci110732.