PMID- 7177152
OWN - NLM
STAT- MEDLINE
DCOM- 19830225
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 102
IP  - 4
DP  - 1982 Dec
TI  - Comparative mutagenicity of 4 DNA-intercalating agents in L5178Y mouse lymphoma 
      cells.
PG  - 447-55
AB  - The mutagenicity of 4 known intercalating agents acridine orange (AO), quinacrine 
      mustard (QM), proflavin (PF) and ethidium bromide (EB) has been investigated in 
      L5178Y mouse lymphoma cells. Methyl methanesulfonate (MMS) was used as a positive 
      control in these studies. AO, QM and PF induced mutation in the excess thymidine- 
      and thioguanine-selective systems. These 3 compounds were negative in the 
      ouabain- and cytosine-arabinoside-selective systems while EB was positive only in 
      the cytosine arabinoside system. It would appear that the EB-induced mutagenesis 
      is different from that of AO, QM and PF though all are intercalating agents. 
      Since the molecular origin of cytosine arabinoside mutants is unknown, further 
      interpretation of the EB results is not possible.
FAU - Rogers, A M
AU  - Rogers AM
FAU - Back, K C
AU  - Back KC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Acridines)
RN  - 0 (Intercalating Agents)
RN  - 0 (Mutagens)
RN  - 4213-45-0 (Quinacrine Mustard)
RN  - AT5C31J09G (Methyl Methanesulfonate)
RN  - CY3RNB3K4T (Proflavine)
RN  - EN464416SI (Ethidium)
RN  - F30N4O6XVV (Acridine Orange)
RN  - H0C805XYDE (Quinacrine)
SB  - IM
MH  - Acridine Orange/*pharmacology
MH  - Acridines/*pharmacology
MH  - Animals
MH  - Cell Survival/drug effects
MH  - Ethidium/*pharmacology
MH  - Intercalating Agents/*pharmacology
MH  - Leukemia L5178/*genetics/physiopathology
MH  - Leukemia, Experimental/*genetics
MH  - Methyl Methanesulfonate/pharmacology
MH  - Mice
MH  - *Mutagens
MH  - Mutation
MH  - Proflavine/*pharmacology
MH  - Quinacrine/*analogs & derivatives
MH  - Quinacrine Mustard/*pharmacology
EDAT- 1982/12/01 00:00
MHDA- 1982/12/01 00:01
CRDT- 1982/12/01 00:00
PHST- 1982/12/01 00:00 [pubmed]
PHST- 1982/12/01 00:01 [medline]
PHST- 1982/12/01 00:00 [entrez]
AID - 0165-1218(82)90107-0 [pii]
AID - 10.1016/0165-1218(82)90107-0 [doi]
PST - ppublish
SO  - Mutat Res. 1982 Dec;102(4):447-55. doi: 10.1016/0165-1218(82)90107-0.