PMID- 7183030
OWN - NLM
STAT- MEDLINE
DCOM- 19830729
LR  - 20191031
IS  - 0341-0382 (Print)
IS  - 0341-0382 (Linking)
VI  - 37
IP  - 11-12
DP  - 1982 Nov-Dec
TI  - Biological activities of sesquiterpene lactones from Helianthus annuus: 
      antimicrobial and cytotoxic properties; influence on DNA, RNA, and protein 
      synthesis.
PG  - 1087-91
AB  - Sesquiterpene lactones, produced in light and capable of inhibiting auxin-induced 
      elongation growth of coleoptile and hypocotyl segments, were isolated from young 
      leaves of Helianthus annuus (Spring and Hager, Planta in press, 1982). These 
      compounds have an antibiotic effect on gram-negative and gram-positive bacteria 
      as well as on some fungi. The minimal inhibiting concentration (MIC) of compound 
      II (15-hydroxy-3-dehydrodesoxyfruticin, Fig. 1), for example, is 15 micrograms/ml 
      for Bacillus brevis, and 95 micrograms/ml for the fungus Eremothecium ashbyi. In 
      addition, cytotoxic effects on mouse myeloma cells (NS-1) were also shown. 
      Compound II causes a 50% inhibition of cell proliferation (ED50) at a 
      concentration of 170 nM, compound I (niveusin C, Fig. 1) at 220 nM. The 
      LD50-values were 0.15 micrograms II/ml and 1.24 micrograms I/ml, respectively. By 
      measuring 14C-labelled thymidine, uridine and leucine incorporation into murine 
      cells of the ascitic form of Ehrlich carcinoma (EAC) it could be shown that 
      compounds I and II inhibit DNA and RNA synthesis, but do not affect the 
      translation processes involved in protein synthesis. Furthermore, it could be 
      shown that the exocyclic methylene group in the molecules of I and II plays an 
      important role in triggering the described inhibitory effects.
FAU - Spring, O
AU  - Spring O
FAU - Kupka, J
AU  - Kupka J
FAU - Maier, B
AU  - Maier B
FAU - Hager, A
AU  - Hager A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Z Naturforsch C Biosci
JT  - Zeitschrift fur Naturforschung. Section C, Biosciences
JID - 7801143
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antifungal Agents)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (Sesquiterpenes)
SB  - IM
MH  - Animals
MH  - *Anti-Bacterial Agents
MH  - *Antifungal Agents
MH  - Bacteria/*drug effects
MH  - Carcinoma, Ehrlich Tumor/metabolism
MH  - Cell Survival/drug effects
MH  - DNA Replication/*drug effects
MH  - DNA, Neoplasm/genetics
MH  - Fungi/drug effects
MH  - Mice
MH  - Plants, Medicinal/*analysis
MH  - Plasmacytoma/physiopathology
MH  - Protein Biosynthesis/*drug effects
MH  - RNA, Neoplasm/genetics
MH  - Sesquiterpenes/isolation & purification/*pharmacology
MH  - Species Specificity
MH  - Transcription, Genetic/*drug effects
EDAT- 1982/11/01 00:00
MHDA- 1982/11/01 00:01
CRDT- 1982/11/01 00:00
PHST- 1982/11/01 00:00 [pubmed]
PHST- 1982/11/01 00:01 [medline]
PHST- 1982/11/01 00:00 [entrez]
AID - 10.1515/znc-1982-11-1207 [doi]
PST - ppublish
SO  - Z Naturforsch C Biosci. 1982 Nov-Dec;37(11-12):1087-91. doi: 
      10.1515/znc-1982-11-1207.