PMID- 7190925
OWN - NLM
STAT- MEDLINE
DCOM- 19801124
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 65
IP  - 4
DP  - 1980 Aug 8
TI  - Methionine-enkephalin antagonism and endorphin potentiation of narcotic-induced 
      analgesia.
PG  - 369-77
AB  - Intracerebroventricular (i.c.v.) administration of subanalgesic doses of beta- 
      and leucine-endorphin in mice 15 min before subcutaneous morphine injection, 
      significantly enhanced the analgesic effects of the morphine as measured by the 
      tail-flick assay. A similar effect was seen with levorphanol analgesia but not 
      enhancement of leucine- or methionine-enkephalin analgesia by beta-endorphin was 
      observed. The same doses of the endorphins did not affect the development of 
      single-dose morphine tolerance and dependence. Leucine-enkephalin failed to 
      affect morphine analgesia, tolerance or dependence development, while low doses 
      of methionine-enkephalin administered i.c.v. were observed to have an 
      antagonistic effect on morphine analgesia without affecting tolerance or 
      dependence development. Neither endephalin had any effect on beta-endorphin 
      analgesia.
FAU - Chapman, D B
AU  - Chapman DB
FAU - Hu, J
AU  - Hu J
FAU - Way, E L
AU  - Way EL
LA  - eng
GR  - DA-00037/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Endorphins)
RN  - 0 (Enkephalins)
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Drug Interactions
MH  - Drug Tolerance
MH  - Endorphins/*pharmacology
MH  - Enkephalin, Methionine
MH  - Enkephalins/*pharmacology
MH  - Guinea Pigs
MH  - Humans
MH  - In Vitro Techniques
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Morphine/*pharmacology
MH  - Morphine Dependence/physiopathology
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth/drug effects
MH  - Reaction Time/drug effects
EDAT- 1980/08/08 00:00
MHDA- 1980/08/08 00:01
CRDT- 1980/08/08 00:00
PHST- 1980/08/08 00:00 [pubmed]
PHST- 1980/08/08 00:01 [medline]
PHST- 1980/08/08 00:00 [entrez]
AID - 0014-2999(80)90341-6 [pii]
AID - 10.1016/0014-2999(80)90341-6 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1980 Aug 8;65(4):369-77. doi: 10.1016/0014-2999(80)90341-6.