PMID- 7195156
OWN - NLM
STAT- MEDLINE
DCOM- 19810709
LR  - 20190821
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 36
IP  - 3
DP  - 1981 Apr
TI  - Effect in man of anti-allergic drugs on the immediate and late phase cutaneous 
      allergic reactions induced by anti-IgE.
PG  - 201-8
AB  - Wheal and flare reactions as well as a late cutaneous allergic reaction (LCAR) 
      were induced by anti-human IgE in healthy subjects. The effect of the beta 
      2-adrenoceptor stimulant terbutaline, the histamine-1 (H1) receptor blocking 
      agent mepyramine and the synthetic glucocorticoid betamethasone on these 
      reactions was studied. All administrations were given intradermally (i.d.). The 
      immediate reaction to anti-IgE was inhibited by 3 micrograms terbutaline and 30 
      micrograms mepyramine (P less than 0.01) whereas 50 micrograms betamethasone had 
      no effects. Terbutaline had no effect on the flare response induced by i.d. 
      injected histamine but a slight effect on whealing. Terbutaline and mepyramine 
      weakly reduced the LCAR throughout the observation period of 24 h (P less than 
      0.01). In contrast, betamethasone almost completely abolished the LCAR. It is 
      concluded that the two phases of the skin reaction to anti-IgE are interrelated 
      since an inhibition of the early phase was followed by an attenuation of the 
      LCAR. The mechanism of action of steroids seems to differ fundamentally from that 
      of other anti-allergic drugs since inhibition of the early step in the reaction 
      is not essential to the action on the late step. It is further suggested that 
      terbutaline inhibits anti-IgE-mediated cutaneous reactions by inhibition of the 
      mast cell release reaction.
FAU - Gronneberg, R
AU  - Gronneberg R
FAU - Strandberg, K
AU  - Strandberg K
FAU - Stalenheim, G
AU  - Stalenheim G
FAU - Zetterstrom, O
AU  - Zetterstrom O
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Immune Sera)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9842X06Q6M (Betamethasone)
RN  - HPE317O9TL (Pyrilamine)
RN  - N8ONU3L3PG (Terbutaline)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Antigen-Antibody Reactions/*drug effects
MH  - Betamethasone/therapeutic use
MH  - Humans
MH  - Hypersensitivity, Immediate/drug therapy
MH  - Immune Sera
MH  - Immunoglobulin E/*immunology
MH  - Injections, Intradermal
MH  - Middle Aged
MH  - Pyrilamine/therapeutic use
MH  - Sheep/immunology
MH  - Skin/*immunology
MH  - Terbutaline/therapeutic use
MH  - Time Factors
EDAT- 1981/04/01 00:00
MHDA- 1981/04/01 00:01
CRDT- 1981/04/01 00:00
PHST- 1981/04/01 00:00 [pubmed]
PHST- 1981/04/01 00:01 [medline]
PHST- 1981/04/01 00:00 [entrez]
AID - 10.1111/j.1398-9995.1981.tb01835.x [doi]
PST - ppublish
SO  - Allergy. 1981 Apr;36(3):201-8. doi: 10.1111/j.1398-9995.1981.tb01835.x.