PMID- 7195241
OWN - NLM
STAT- MEDLINE
DCOM- 19810709
LR  - 20121115
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 31
IP  - 1a
DP  - 1981
TI  - A new non-glycoside, non-adrenergic cardiotonic agent AR-L 115 BS. Hemodynamic 
      proof of its efficacy after both i.v. and oral administration.
PG  - 273-8
AB  - In 11 patients with New York Heart Association (NYHA) functional class III-IV 
      symptoms we monitored the effect of 
      2-[(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4.5-b]pyridine (AR-L 115 BS). 
      Heart rate (HR), pulmonary arterial mean pressure (PAM), aortic systolic pressure 
      (AoSP) and thermodilution cardiac output (CO) were measured before and up to 25 
      min after a bolus of AR-L 115 BS, 3 mg/kg body weight, i.v. The oral effect of 
      AR-L 115, 200 mg, 3 times daily, was monitored in 18 patients with congestive 
      cardiomyopathy (CC) over a period of 4 days. AR-L 115 BS is also orally active 
      and thus is a very promising inotropic agent for the treatment of chronic heart 
      failure in man.
FAU - Thormann, J
AU  - Thormann J
FAU - Kramer, W
AU  - Kramer W
FAU - Schlepper, M
AU  - Schlepper M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Imidazoles)
RN  - HK56EH9K44 (sulmazole)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Cardiotonic Agents/administration & dosage/*therapeutic use
MH  - Female
MH  - Heart Diseases/*drug therapy/physiopathology
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Imidazoles/*therapeutic use
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Time Factors
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1981;31(1a):273-8.