PMID- 7195381
OWN - NLM
STAT- MEDLINE
DCOM- 19810827
LR  - 20190816
IS  - 0020-5915 (Print)
IS  - 0020-5915 (Linking)
VI  - 65
IP  - 3
DP  - 1981
TI  - Immunoglobulin E-containing cells in mouse lung following allergen inhalation and 
      ozone exposure.
PG  - 266-77
AB  - Cells containing immunoglobulin E (IgE) were enumerated and their location in 
      mouse lungs was determined by direct immunofluorescence. Lungs were studied from 
      mice that had been immunized with aerosolized ovalbumin as well as from normal 
      mice and from mice that were exposed to ozone (0.5 or 0.8 ppm) prior to receiving 
      aerosolized antigen. In addition, some mice were immunized intraperitoneally with 
      ovalbumin precipitated in alum. IgE-containing cells were primarily 
      airway-related in normal mice and in mice immunized by the intraperitoneal route. 
      Lungs from aerosol-immunized, and aerosol-immunized ozone-exposed mice showed a 
      more disseminated distribution of IgE-containing cells. Fluorescent cells were 
      counted and numbers were expressed as total cells per square millimeter of lung 
      tissue and as airway-associated cells per millimeter of airway. Total IgE cells 
      increased 9.4-fold in mice that received aerosolized ovalbumin as compared to 
      normal mice. When ozone exposure was added to the effects from aerosolized 
      ovalbumin, the increase of IgE cells over normal was 34.2-fold. IgE cell counts 
      correlated well with anaphylactic sensitivity to intravenous challenge with 
      ovalbumin. The observed enhancement of allergic sensitization by ozone exposure 
      has important implications for human health.
FAU - Gershwin, L J
AU  - Gershwin LJ
FAU - Osebold, J W
AU  - Osebold JW
FAU - Zee, Y C
AU  - Zee YC
LA  - eng
GR  - 5501RR5457/RR/NCRR NIH HHS/United States
GR  - GM 762/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Int Arch Allergy Appl Immunol
JT  - International archives of allergy and applied immunology
JID - 0404561
RN  - 0 (Aerosols)
RN  - 0 (Allergens)
RN  - 0 (Antibodies)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 66H7ZZK23N (Ozone)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Intranasal
MH  - Aerosols
MH  - Allergens/*administration & dosage
MH  - Anaphylaxis/immunology
MH  - Animals
MH  - Antibodies
MH  - Antibody-Producing Cells/*immunology
MH  - Female
MH  - *Immunoglobulin E
MH  - Injections, Intraperitoneal
MH  - Lung/*immunology
MH  - Mice
MH  - Ovalbumin/immunology
MH  - Ozone/pharmacology
MH  - Passive Cutaneous Anaphylaxis
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
AID - 10.1159/000232766 [doi]
PST - ppublish
SO  - Int Arch Allergy Appl Immunol. 1981;65(3):266-77. doi: 10.1159/000232766.