PMID- 7198187
OWN - NLM
STAT- MEDLINE
DCOM- 19820225
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 31
IP  - 11
DP  - 1981 Nov
TI  - Bicuculline: a convulsant with synaptic and nonsynaptic actions.
PG  - 1381-90
AB  - The convulsant bicuculline (BICUC) had both synaptic and nonsynaptic actions on 
      mouse spinal cord neurons in primary dissociated cell culture. BICUC antagonized 
      postsynaptic responses to the inhibitory neurotransmitter GABA (a synaptic 
      action) and produced direct membrane depolarization by blocking a membrane 
      potassium conductance and directly prolonging calcium-dependent action potentials 
      (nonsynaptic actions). In cultured spinal cord neurons, BICUC also produced 
      paroxysmal depolarizing events (PDE), which might be equivalent to in vivo 
      convulsant-induced bursting in spinal cord neurons or paroxysmal depolarizing 
      shifts (PDS) in cortical neurons. Thus, the concentrations of BICUC producing 
      both synaptic and nonsynaptic actions overlapped those producing paroxysmal 
      activity. The results suggest that in addition to antagonism of GABA-mediated 
      synaptic inhibition, direct nonsynaptic actions of BICUC may be required for some 
      neurons to develop PDS.
FAU - Heyer, E J
AU  - Heyer EJ
FAU - Nowak, L M
AU  - Nowak LM
FAU - Macdonald, R L
AU  - Macdonald RL
LA  - eng
GR  - NS 00408/NS/NINDS NIH HHS/United States
GR  - NS 15225/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - SY7Q814VUP (Calcium)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Bicuculline/*pharmacology
MH  - Calcium/pharmacology
MH  - Cells, Cultured
MH  - Electrophysiology
MH  - Ganglia, Spinal/cytology/physiopathology
MH  - Membrane Potentials/drug effects
MH  - Mice
MH  - Spinal Cord/cytology/physiopathology
MH  - Synaptic Membranes/*physiopathology
MH  - gamma-Aminobutyric Acid/pharmacology
EDAT- 1981/11/01 00:00
MHDA- 1981/11/01 00:01
CRDT- 1981/11/01 00:00
PHST- 1981/11/01 00:00 [pubmed]
PHST- 1981/11/01 00:01 [medline]
PHST- 1981/11/01 00:00 [entrez]
AID - 10.1212/wnl.31.11.1381 [doi]
PST - ppublish
SO  - Neurology. 1981 Nov;31(11):1381-90. doi: 10.1212/wnl.31.11.1381.