PMID- 7198188
OWN - NLM
STAT- MEDLINE
DCOM- 19820225
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 31
IP  - 11
DP  - 1981 Nov
TI  - Circulating immune complexes in neurologic disease.
PG  - 1402-7
AB  - Sera from patients with multiple sclerosis (MS), amyotrophic lateral sclerosis 
      (ALS), subacute sclerosing panencephalitis (SSPE), and myasthenia gravis (MG) 
      were assayed for immune complexes. Three techniques were used: a modified Raji 
      cell assay, the 125I-Clq polyethyleneglycol assay, and a solid-phase clq assay. 
      Immune complex levels were elevated in sera of some patients with MS, ALS, and 
      SSPE, but the elevations were modest when compared with active systemic lupus 
      erythematosus (SLE). In some cases, abnormalities were detected in only one assay 
      system; in other cases, abnormalities were detected by two or three assay 
      systems. In MS, immune complex elevations correlated with active disease and with 
      decreased suppressor cell activity. Of two ALS patients with antecedent 
      poliomyelitis, one had markedly increased levels of immune complexes in two 
      assays. In MG, levels of immune complexes did not differ from those of controls.
FAU - Noronha, A B
AU  - Noronha AB
FAU - Antel, J P
AU  - Antel JP
FAU - Roos, R P
AU  - Roos RP
FAU - Medof, M E
AU  - Medof ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Antigen-Antibody Complex)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/immunology
MH  - Antigen-Antibody Complex/*analysis
MH  - Humans
MH  - Lupus Erythematosus, Systemic/immunology
MH  - Middle Aged
MH  - Multiple Sclerosis/immunology
MH  - Myasthenia Gravis/immunology
MH  - Nervous System Diseases/*immunology
MH  - Precipitin Tests
MH  - Radioimmunoassay
MH  - Subacute Sclerosing Panencephalitis/immunology
EDAT- 1981/11/01 00:00
MHDA- 1981/11/01 00:01
CRDT- 1981/11/01 00:00
PHST- 1981/11/01 00:00 [pubmed]
PHST- 1981/11/01 00:01 [medline]
PHST- 1981/11/01 00:00 [entrez]
AID - 10.1212/wnl.31.11.1402 [doi]
PST - ppublish
SO  - Neurology. 1981 Nov;31(11):1402-7. doi: 10.1212/wnl.31.11.1402.