PMID- 7198927
OWN - NLM
STAT- MEDLINE
DCOM- 19820412
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 231
IP  - 2
DP  - 1982 Jan 14
TI  - Involvement of GABA in the feedback action of estradiol on gonadotropin and 
      prolactin release: hypothalamic GABA and catecholamine turnover rates.
PG  - 353-64
AB  - The concentrations and turnover rates of norepinephrine (NE), dopamine (DA) and 
      gamma-aminobutyric acid (GABA) were measured in discrete brain areas of diestrous 
      (D), proestrous (P), ovariectomized (OVX) and ovariectomized rats treated with 
      estradiol-benzoate (EB) 12 or 24 h before decapitation. The turnover of NE in the 
      medial preoptic area (MPO) correlates well with plasma LH levels under all 
      endocrine conditions showing high NE turnover in P and OVX and low NE turnover in 
      D and OVX-EB animals. The DA turnover shows no hormone-dependent changes in the 
      MPO. In those animals where estrogens exert no (OVX) or a negative feedback 
      action (D, OVX-EB) on LH the GABA turnover correlates inversely with LH and 
      preoptic NE turnover showing low GABA turnover values in OVX and high values in D 
      and OVX-EB. For P animals the inverse correlation cannot be confirmed. It is 
      concluded that GABA mediates the negative feedback action of estrogens to LH-RH 
      perikarya located in the MPO. GABA might act by presynaptic inhibition of NE axon 
      terminals. This hypothesis is supported by morphological findings which indicate 
      that axon terminals in the MPO are in close contact without separating glial 
      lamellae. In the anterior mediobasal hypothalamus (AMBH) NE turnover correlates 
      best with serum prolactin levels being high in P and OVX animals 24 h after EB 
      treatment. The DA turnover is increased in OVX rats 24 h after EB. It is not yet 
      clear if this increase might be a consequence of the elevated prolactin levels. 
      GABA turnover in the AMBH shows no significant changes. GABA concentrations and 
      turnover rates were also determined in the mediocortical amygdala where estrogen 
      receptors have been reported and in the nucleus accumbens. No significant changes 
      could be observed in these regions.
FAU - Mansky, T
AU  - Mansky T
FAU - Mestres-Ventura, P
AU  - Mestres-Ventura P
FAU - Wuttke, W
AU  - Wuttke W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 4TI98Z838E (Estradiol)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*metabolism/ultrastructure
MH  - Castration
MH  - Dopamine/*metabolism
MH  - Estradiol/*pharmacology
MH  - *Estrus
MH  - Feedback
MH  - Female
MH  - Kinetics
MH  - Male
MH  - Microscopy, Electron
MH  - Norepinephrine/*metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - gamma-Aminobutyric Acid/*metabolism
EDAT- 1982/01/14 00:00
MHDA- 1982/01/14 00:01
CRDT- 1982/01/14 00:00
PHST- 1982/01/14 00:00 [pubmed]
PHST- 1982/01/14 00:01 [medline]
PHST- 1982/01/14 00:00 [entrez]
AID - 0006-8993(82)90372-9 [pii]
AID - 10.1016/0006-8993(82)90372-9 [doi]
PST - ppublish
SO  - Brain Res. 1982 Jan 14;231(2):353-64. doi: 10.1016/0006-8993(82)90372-9.