PMID- 7200000
OWN - NLM
STAT- MEDLINE
DCOM- 19820624
LR  - 20221207
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 81
IP  - 4
DP  - 1982 Apr
TI  - HLA linkage vs association in hypertrophic cardiomyopathy. Evidence for the 
      absence of an association in a heterogeneous Caucasian population.
PG  - 466-72
AB  - Human leukocyte antigen (HLA) tissue-typing studies on patients with genetically 
      transmitted hypertrophic cardiomyopathy have demonstrated an HLA linkage in a 
      Caucasian and black patient group and an HLA-DR locus association in a Japanese 
      population sample. To confirm whether a specific HLA antigen(s) might serve as a 
      marker for hypertrophic cardiomyopathy, we performed tissue-typing studies on 50 
      unrelated, normotensive North American Caucasians with the disorder. Patients 
      were subdivided into three hemodynamic subgroups: obstructive (35), provocable 
      (ten), and nonobstructive (five). Although there was an increased frequency of 
      the B12 and AW32 HLA antigens in the total group, after correction of P values 
      for the number of antigens studied, the associations were not statistically 
      significant. Analysis of the HLA antigen frequencies in the three hemodynamic 
      subgroups yielded no statistically significant HLA-A, B, or C locus associations, 
      and no unusual deviation in linkage disequilibrium between A and B locus antigens 
      was observed. We conclude that although on the sixth chromosome there may be a 
      susceptibility gene for hypertrophic cardiomyopathy, which segregates with a 
      specific haplotype in a given family, no specific HLA-A, B, or C locus antigen 
      was found useful as a marker. HLA-DR locus antigen typing might prove useful in 
      this population.
FAU - Gardin, J M
AU  - Gardin JM
FAU - Gottdiener, J S
AU  - Gottdiener JS
FAU - Radvany, R
AU  - Radvany R
FAU - Maron, B J
AU  - Maron BJ
FAU - Lesch, M
AU  - Lesch M
LA  - eng
GR  - RR-05370/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*genetics
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, 6-12 and X/*ultrastructure
MH  - Female
MH  - Genes
MH  - *Genetic Linkage
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - North America
MH  - Pedigree
MH  - Risk
MH  - White People
EDAT- 1982/04/01 00:00
MHDA- 1982/04/01 00:01
CRDT- 1982/04/01 00:00
PHST- 1982/04/01 00:00 [pubmed]
PHST- 1982/04/01 00:01 [medline]
PHST- 1982/04/01 00:00 [entrez]
AID - S0012-3692(15)44595-7 [pii]
AID - 10.1378/chest.81.4.466 [doi]
PST - ppublish
SO  - Chest. 1982 Apr;81(4):466-72. doi: 10.1378/chest.81.4.466.