PMID- 7200039
OWN - NLM
STAT- MEDLINE
DCOM- 19820614
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 46
IP  - 1
DP  - 1982
TI  - In vivo GABA release from the medial preoptic area of diestrous and 
      ovariectomized rats.
PG  - 69-72
AB  - The push-pull cannula technique was used to examine the endogenous release of 
      GABA from the medial preoptic area (MPO) of unanesthetized rats. In diestrous 
      females the mean resting release of GABA was 27.1 +/- 2.0 pmol/min. GABA release 
      was significantly elevated by increasing the potassium concentration in the 
      perfusion solution to 50 mM, whereas it was dramatically inhibited by 
      mercaptoproprionic acid (1.0 mM), a glutamic acid decarboxylase inhibitor. A 
      comparison between diestrous females and chronically castrated animals indicated 
      that endogenous GABA release in OVX animals was only 60-70% of that in diestrous 
      animals. A model for the presynaptic inhibition of NE by estrogen receptive 
      GABAergic neurons in the MPO is proposed.
FAU - Ondo, J
AU  - Ondo J
FAU - Mansky, T
AU  - Mansky T
FAU - Wuttke, W
AU  - Wuttke W
LA  - eng
GR  - HD 00248/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - *Castration
MH  - *Diestrus
MH  - *Estrus
MH  - Female
MH  - Hypothalamus/*metabolism
MH  - Luteinizing Hormone/blood
MH  - Pregnancy
MH  - Preoptic Area/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - gamma-Aminobutyric Acid/*metabolism
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1007/BF00238099 [doi]
PST - ppublish
SO  - Exp Brain Res. 1982;46(1):69-72. doi: 10.1007/BF00238099.