PMID- 7203395
OWN - NLM
STAT- MEDLINE
DCOM- 19810513
LR  - 20131121
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 12
IP  - 12
DP  - 1980 Dec
TI  - Adaptive changes in uterine distribution of lactate dehydrogenase isoenzymes 
      during protein malnutrition and steroid maintained pregnancy in rats.
PG  - 697-701
AB  - The electrophoretic studies revealed that in non-pregnant and pregnant rats fed 
      with protein-free diet (PFD), a significant increase in percentage of LDH1 and 
      LDH2 (H-isozymes) was observed with a concomitant decrease in concentration of 
      LDH4 and LDH5 (M-isozymes). The changes in LDH3 were not significant. Further, 
      during protein deficiency heart-type activity (H-subunits) was increased markedly 
      with a parallel decline in muscle-type activity; thus resulting in an increase in 
      H/M ratio or analogue ratio (A.R.). However, the decrease in A.R. (below 2.00), 
      observed during normal and steroid maintained pregnancy was due to higher 
      muscle-type than heart-type activity. These observations suggest that protein 
      malnutrition in rats favours a metabolic shift from anaerobic state to aerobic 
      predominance in the uterus. The physiological significance of these adaptations 
      has been discussed.
FAU - Singh, R K
AU  - Singh RK
FAU - Roy, S K
AU  - Roy SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Isoenzymes)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Animals
MH  - Estradiol/pharmacology
MH  - Female
MH  - Isoenzymes
MH  - L-Lactate Dehydrogenase/*metabolism
MH  - Pregnancy
MH  - Pregnancy Complications/*enzymology
MH  - Progesterone/pharmacology
MH  - Protein Deficiency/*enzymology
MH  - Rats
MH  - Uterus/drug effects/*enzymology
EDAT- 1980/12/01 00:00
MHDA- 1980/12/01 00:01
CRDT- 1980/12/01 00:00
PHST- 1980/12/01 00:00 [pubmed]
PHST- 1980/12/01 00:01 [medline]
PHST- 1980/12/01 00:00 [entrez]
AID - 10.1055/s-2007-999235 [doi]
PST - ppublish
SO  - Horm Metab Res. 1980 Dec;12(12):697-701. doi: 10.1055/s-2007-999235.