PMID- 72074
OWN - NLM
STAT- MEDLINE
DCOM- 19771229
LR  - 20131121
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 45
IP  - 4
DP  - 1977 Oct
TI  - Altered metabolism of androgens in elderly men with benign prostatic hyperplasia.
PG  - 695-701
AB  - Kinetics of testosterone, dihydrotestosterone (DHT) and 
      5alpha-androstane-3alpha,17beta-diol (3alpha-diol) were studied in 7 elderly 
      healthy men (ages 61 to 80 years) with benign prostatic hyperplasia (BPH). 
      Clearance rates were determined by the constant infusion technique with labeled 
      testosterone and DHT. Metabolic clearance rate (MCR), conversion ratio (CR), the 
      transfer constants (rho) and production rates (PB) were calculated. Plasma 
      androgens were measured by specific radioimmunoassay. Plasma testosterone was 516 
      +/- 314 (SD) ng/dl, plasma DHT was 74.6 +/- 19.6 (SD) ng/dl and plasma 
      3alpha-diol was 16.4 +/- 4.1 (SD) ng/dl. An elevated DHT level in elderly men 
      with BPH wasconfirmed. MCRT was 620 +/- 65 (SD) liter/day and MCRDHT was 393 +/- 
      50 (SD) liter/day. Both MCRT and MCRDHT in elderly men were significantly lower 
      than in young men. PBT was 3.2 +/- 2.1 (SD) mg/day and PBDHT was 291 +/- 87 
      (SD)migrogram/day. PBDHT was the same in elderly and young men. DHT production is 
      maintained in elderly men despite reduction of testosterone production. From the 
      data, it was claculated that in contrast to young men where greater than 80% of 
      blood DHT is from secreted testosterone, over 50% in elderly men is derived from 
      secretion or production of DHT by the testis or even more likely the prostate.
FAU - Ishimaru, T
AU  - Ishimaru T
FAU - Pages, L
AU  - Pages L
FAU - Horton, R
AU  - Horton R
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Androstanes)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Aging
MH  - Androstane-3,17-diol/*metabolism
MH  - Androstanes/*metabolism
MH  - Dihydrotestosterone/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostatic Hyperplasia/*metabolism
MH  - Testosterone/*metabolism
EDAT- 1977/10/01 00:00
MHDA- 1977/10/01 00:01
CRDT- 1977/10/01 00:00
PHST- 1977/10/01 00:00 [pubmed]
PHST- 1977/10/01 00:01 [medline]
PHST- 1977/10/01 00:00 [entrez]
AID - 10.1210/jcem-45-4-695 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1977 Oct;45(4):695-701. doi: 10.1210/jcem-45-4-695.