PMID- 7212872
OWN - NLM
STAT- MEDLINE
DCOM- 19810526
LR  - 20131121
IS  - 0003-9780 (Print)
IS  - 0003-9780 (Linking)
VI  - 248
IP  - 1
DP  - 1980 Nov
TI  - Antagonism of some central effects of d-tubocurarine by gamma-aminobutyric acid.
PG  - 148-53
AB  - d-Tubocurarine (dtc) administered intracerebroventricularly (icv) to rats 
      produced seizures. Gamma-aminobutyric acid (GABA) administered icv or 
      hydroxylamine administered intraperitoneally (ip) protected the rats from 
      dtc-induced seizures. GABA administered (ip) was ineffective. Local application 
      of dtc to the spinal cord in decerebrate dogs produced facilitation of the 
      scratch reflex. Application of GABA to the spinal cord inhibition the scratch 
      reflex. It is thus concluded that the excitatory effects of dtc on the CNS may be 
      through inhibition of naturally occurring inhibitory substances such as GABA or a 
      closely related compound.
FAU - Dhumal, V R
AU  - Dhumal VR
FAU - Bhavsar, V H
AU  - Bhavsar VH
LA  - eng
PT  - Journal Article
PL  - Belgium
TA  - Arch Int Pharmacodyn Ther
JT  - Archives internationales de pharmacodynamie et de therapie
JID - 0405353
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - W9YXS298BM (Tubocurarine)
SB  - IM
MH  - Animals
MH  - Decerebrate State
MH  - Female
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Reflex/drug effects
MH  - Seizures/chemically induced
MH  - Species Specificity
MH  - Tubocurarine/*antagonists & inhibitors
MH  - gamma-Aminobutyric Acid/*pharmacology
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
PST - ppublish
SO  - Arch Int Pharmacodyn Ther. 1980 Nov;248(1):148-53.