PMID- 7213038
OWN - NLM
STAT- MEDLINE
DCOM- 19810528
LR  - 20121115
IS  - 0098-6127 (Print)
IS  - 0098-6127 (Linking)
VI  - 8
IP  - 3
DP  - 1980
TI  - Alteration of chromatin in early experimental arteriosclerosis.
PG  - 288-93
AB  - Our approach serves several purposes: To demonstrate the response of aortic cell 
      nuclei to a changing environment (e.g. hypercholesterolemia, experimental 
      diabetes, drug treatment), to apply the acridine orange (AO) ultracytochemical 
      method, and to determine the euchromatin/heterochromatin (EU/HET) ratio by 
      morphometric procedures as suitable criteria, and to emphasize the differential 
      nuclear activity of adventitial cells. Hypercholesterolemia in rabbits results in 
      an increase of AO positive nuclei in the adventitia. Additional treatment with 
      tinofedrine, a new cerebral vasodilator drug, reveals an even higher number of AO 
      positive nuclei in adventitial and also in endothelial and plaque cells. In 
      streptozotocin induced diabetes in rats the increased number of AO positive cells 
      coincides with an elevated EU/HET ratio.
FAU - Lehmann, R
AU  - Lehmann R
FAU - Denes, R
AU  - Denes R
FAU - Nienhaus, R
AU  - Nienhaus R
FAU - Steinbach, T
AU  - Steinbach T
FAU - Lusztig, G
AU  - Lusztig G
FAU - Sanatger, R M
AU  - Sanatger RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Artery
JT  - Artery
JID - 7508494
RN  - 0 (Chromatin)
RN  - 0 (Thiophenes)
RN  - OVJ0W8F17T (tinofedrine)
SB  - IM
MH  - Animals
MH  - Arteriosclerosis/*physiopathology
MH  - Chromatin/*physiopathology/ultrastructure
MH  - Diabetes Mellitus, Experimental/physiopathology
MH  - Hypercholesterolemia/physiopathology
MH  - Rabbits
MH  - Rats
MH  - Thiophenes/pharmacology
MH  - Time Factors
EDAT- 1980/01/01 00:00
MHDA- 1980/01/01 00:01
CRDT- 1980/01/01 00:00
PHST- 1980/01/01 00:00 [pubmed]
PHST- 1980/01/01 00:01 [medline]
PHST- 1980/01/01 00:00 [entrez]
PST - ppublish
SO  - Artery. 1980;8(3):288-93.