PMID- 721369
OWN - NLM
STAT- MEDLINE
DCOM- 19790223
LR  - 20181217
VI  - 2
IP  - 3
DP  - 1978
TI  - Dietary and anticholinergic effects on intravenous glucose tolerance and insulin 
      secretion.
PG  - 309-20
AB  - Six normal-weight subjects were fed five separate diets [isocaloric--20, 40 and 
      80 per cent carbohydrate (CHO) and hypercaloric 20 and 40 per cent CHO] for 5 
      days each. Intravenous glucose-tolerance tests were performed on on Day 6. 
      Insulin responses were positively related to caloric and CHO content of the 
      diets, both of which affected insulin secretion independently of each other. 
      Glucose disappearance rates were highly correlated (r = 0.80) with the acute 
      insulin response to glucose. Fasting plasma-glucose levels (FPG) were also 
      affected by both calories and CHO content, but in a more complex manner. Raising 
      CHO content in isocaloric diets or increasing calories in diets of normal CHO 
      content increased FPG. However, if either calories or CHO content were high, 
      increasing the other had no further effect on FPG. Thus, there was an interaction 
      between calories and CHO on FPG. In 18 instances, the diet was continued on Day 6 
      and another intravenous glucose tolerance test was performed the following 
      morning, 90--120 minutes after 30mg of propantheline bromide by mouth. Glucose 
      disappearance rates were increased in 16 of the 18 paired tests (P less than 
      0.005) after the anticholinergic agent. There was no effect on FPG or the insulin 
      response to glucose. CONCLUSIONS: both calories and CHO content are positively 
      related to insulin secretion after 5 days of dietary manipulation. Glucose 
      disappearance rates are also influenced, probably via the effect on insulin 
      secretion. Both increased calories and CHO content will raise FPG; but each will 
      have this effect only in the presence of a normal intake of the other. Thus, 
      unless possible interactions between calories and CHO are taken into 
      consideration in the design and interpretation of future dietary studies, 
      erroneous conclusions may be reached. Finally, cholinergic blockade will enhance 
      the disposal of intravenous glucose in the absence of any effect on peripheral 
      insulin levels.
FAU - Davidson, M B
AU  - Davidson MB
FAU - Forsythe, A B
AU  - Forsythe AB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Obes
JT  - International journal of obesity
JID - 7703240
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 1306V2B0Q8 (Propantheline)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Body Weight
MH  - *Diet
MH  - Dietary Carbohydrates/*adverse effects
MH  - *Energy Intake
MH  - Fasting
MH  - Glucose/*administration & dosage
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hyperinsulinism
MH  - Injections, Intravenous
MH  - Insulin/*metabolism
MH  - Insulin Secretion
MH  - Male
MH  - Pancreas/physiology
MH  - Propantheline/*administration & dosage
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
PST - ppublish
SO  - Int J Obes. 1978;2(3):309-20.