PMID- 7237012
OWN - NLM
STAT- MEDLINE
DCOM- 19810810
LR  - 20151119
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 54
IP  - 641
DP  - 1981 May
TI  - Synthetic porphyrins as tumour-localizing agents.
PG  - 403-7
AB  - A series of radioactively labelled porphyrin analogues have been synthesized and 
      compared for tissue distribution and tumour uptake against 67Ga in the same 
      tumour-mouse system. The compounds were: 14C-ms-tetraphenylporphine sulphonate 
      (14C-TPPS), 35S-ms-tetraphenylporphine sulphonate (TPP35S), 
      35S-ms-tetra[beta-naphthyl]porphine sulphonate (TNP35S), 
      14C-ms-thienylphenylporphine sulphonate (14C-TTPPS) and 
      35S-ms-tetra[p-tolyl]porphine sulphonate (TTP35S). 14C-TPPS and TNP35S appear to 
      concentrate in tumours to a greater extent than 67Ga (ratios of tumour uptake for 
      TPPS/67Ga and TNPS/67Ga were about two and three respectively) but their uptake 
      in kidneys and lungs was also greater than that of gallium. The type of side 
      group attached to the central tetrapyrrole ring appears to have a substantial 
      effect on the tumour-localizing properties of these compounds. Comparison of 14C 
      and 35S-labeled TPPS indicates that the sulphonate groups are split off in vivo 
      and that compounds with highly aromatic side groups (e.g. TNPS) and a radioactive 
      label in a non-labile part of the molecule (e.g. in the tetrapyrrole ring system 
      itself) would show even better tumour localization. The feasibility of 
      synthesizing porphyrins with a variety of reactive side groups suggests that it 
      may be possible to introduce suitable gamma-emitters while retaining the 
      tumour-localizing properties.
FAU - Zanelli, G D
AU  - Zanelli GD
FAU - Kaelin, A C
AU  - Kaelin AC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Gallium Radioisotopes)
RN  - 0 (Porphyrins)
RN  - 0 (Sulfur Radioisotopes)
SB  - IM
MH  - Animals
MH  - Carbon Radioisotopes
MH  - Gallium Radioisotopes
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Neoplasms, Experimental/diagnosis/*metabolism
MH  - Porphyrins/*metabolism
MH  - Sulfur Radioisotopes
EDAT- 1981/05/01 00:00
MHDA- 1981/05/01 00:01
CRDT- 1981/05/01 00:00
PHST- 1981/05/01 00:00 [pubmed]
PHST- 1981/05/01 00:01 [medline]
PHST- 1981/05/01 00:00 [entrez]
AID - 10.1259/0007-1285-54-641-403 [doi]
PST - ppublish
SO  - Br J Radiol. 1981 May;54(641):403-7. doi: 10.1259/0007-1285-54-641-403.