PMID- 7238547
OWN - NLM
STAT- MEDLINE
DCOM- 19810810
LR  - 20131121
IS  - 0361-073X (Print)
IS  - 0361-073X (Linking)
VI  - 7
IP  - 1
DP  - 1981 Spring
TI  - Hypothermia produced in aged squirrel monkeys by central administration of 
      taurine.
PG  - 17-24
AB  - Accidental hypothermia and heatstroke are more common in aged populations. While 
      peripheral factors are undoubtedly important to the high incidence of dysthermia 
      in the aged, alterations in central temperature controls associated with aging 
      may be primarily responsible. It has been shown that the sensitivity of the 
      hypothalamus to neurotransmitters is changed in aged animals, and it may be that 
      similar alterations in central temperature controls underlie the increased 
      susceptibility to dysthermia. As a first step in testing this hypothesis the 
      responsiveness of central temperature controls of aged squirrel monkeys to 
      taurine, a putative inhibitory neurotransmitter or neuromodulator, was tested. 
      Intracerebroventricular (i.c.v.) administration of this sulfonated amino acid 
      (0.5-4.0 mg) produced dose-related hypothermia in squirrel monkeys over nine 
      years of age in a thermoneutral environment (23 degrees C). Younger animals had 
      significantly smaller hypothermias. In a hot environment (30 degree C) there were 
      no significant differences between the temperature decreases of the two age 
      groups after any dose. However, in a cold environment (17 degrees C), in which 
      young animals developed slightly larger hypothermias than in the thermoneutral 
      environment, core temperature of the aged squirrel monkeys dropped so rapidly in 
      response to even the lowest dose that they had to be removed and warmed to 
      prevent death by hypothermia. The temperature controls of the aged squirrel 
      monkey appear to be extremely sensitive to taurine. The findings indicate that a 
      rise in central taurine concentration in old primates can, in a cold environment, 
      produce an effect very much like accidental hypothermia in aged man.
FAU - Clark, S M
AU  - Clark SM
FAU - Lipton, J M
AU  - Lipton JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Exp Aging Res
JT  - Experimental aging research
JID - 7603335
RN  - 1EQV5MLY3D (Taurine)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Female
MH  - Hypothermia/chemically induced/*physiopathology
MH  - Male
MH  - Saimiri
MH  - Taurine/*pharmacology
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
AID - 10.1080/03610738108259782 [doi]
PST - ppublish
SO  - Exp Aging Res. 1981 Spring;7(1):17-24. doi: 10.1080/03610738108259782.