PMID- 7239420
OWN - NLM
STAT- MEDLINE
DCOM- 19810820
LR  - 20061115
IS  - 0367-6102 (Print)
IS  - 0367-6102 (Linking)
VI  - 55
IP  - 5
DP  - 1980 Sep
TI  - [Studies on establishment and maintenance of persistent infection with measles 
      virus in NC-37 cell. 1. Production of DNA-synthesis-suppressing factor (DSF) in 
      NC-37 cell infected with measles virus].
PG  - 433-9
AB  - Wild strains of measles virus, such as Edmonston, Toyoshima and freshly isolated 
      KM strain which had not a capacity to establish a persistent infection in NC-37 
      cell inhibited 80-90 percent of host cellular DNA synthesis, while attenuated or 
      subacute sclerosing panencephalitis (SSPE) viruses, such as Schwarz, Halle and 
      Mantooth which had a capacity to establish persistent infection inhibited about 
      50 percent of host cellular DNA synthesis 6 or 7 days after infection of virus. 
      However, inhibition of DNA synthesis in cells infected with attenuated or SSPE 
      virus recovered gradually to the same level of control cell within two weeks 
      after infection of virus, and persistently infected cells were not suppressed 
      cellular DNA synthesis in synchronized cell culture. NC-37 cells infected with 
      wild strain produced host cellular DNA-synthesis-suppressing factor (DSF) into 
      culture fluid, but it could detect no such factor in culture fluid of cells 
      infected with attenuated, SSPE virus, or carried virus and persistently infected 
      cell. Furthermore, persistently infected cell treated wtih DSF caused the 
      suppression of DNA synthesis, and so these cells died of metabolic inhibition 
      within one week after inoculation of DSF. NC-37 cell infected with Mantooth 
      strain was inhibited the establishment of persistent infection by the treatment 
      of cell with DSF.
FAU - Fujii, N
AU  - Fujii N
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Hokkaido Igaku Zasshi
JT  - [Hokkaido igaku zasshi] The Hokkaido journal of medical science
JID - 17410290R
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Cells, Cultured
MH  - DNA/*antagonists & inhibitors/*biosynthesis/physiology
MH  - Humans
MH  - Lymphocytes/*metabolism
MH  - Measles virus/*physiology
EDAT- 1980/09/01 00:00
MHDA- 1980/09/01 00:01
CRDT- 1980/09/01 00:00
PHST- 1980/09/01 00:00 [pubmed]
PHST- 1980/09/01 00:01 [medline]
PHST- 1980/09/01 00:00 [entrez]
PST - ppublish
SO  - Hokkaido Igaku Zasshi. 1980 Sep;55(5):433-9.