PMID- 7246795
OWN - NLM
STAT- MEDLINE
DCOM- 19810827
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 241
IP  - 1
DP  - 1981 Jul
TI  - Acute and chronic changes after aortic valve damage in the intact dog.
PG  - H95-103
AB  - Acute aortic regurgitation was produced under anesthesia in 11 closed-chest dogs 
      previously instrumented with ultrasound transducers. The immediate responses 
      included increases in end-diastolic diameter (EDD), fractional shortening (FS), 
      heart rate, left ventricular end-diastolic pressure (LVEDP), and pulmonary 
      capillary wedge pressure (PCWP), the latter being transient as was a decrease in 
      left ventricular peak systolic pressure (LVSP). End-systolic diameter (ESD) did 
      not change. The grouped data suggest that no further changes occurred following 
      the initial responses except in PCWP and LVSP. The data from individual dogs 
      showed that there was a tendency for EDP, LVEDP, and PCWP to return toward 
      control values after the initial increases in those dogs in which the heart rate 
      increased after valve damage. This suggests that there were ongoing compensatory 
      adjustments after the initial responses in this subgroup. Twelve dogs were 
      followed chronically in the intact conscious state with echocardiographic 
      measurements after acute aortic valve damage. EDD and ESD increased rapidly for 
      about 80 days after which EDD increased slowly, whereas ESD showed no further 
      change. Wall thickness and FS did not change throughout the period of study, 
      suggesting that increasing wall thickness may be a relatively late change and 
      that it may be related to the level of myocardial compensation.
FAU - Belenkie, I
AU  - Belenkie I
FAU - Rademaker, A
AU  - Rademaker A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Aorta/physiopathology
MH  - Aortic Valve/*physiopathology
MH  - Aortic Valve Insufficiency/*physiopathology
MH  - Blood Pressure
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Dogs
MH  - Heart Rate
MH  - Ultrasonography
EDAT- 1981/07/01 00:00
MHDA- 1981/07/01 00:01
CRDT- 1981/07/01 00:00
PHST- 1981/07/01 00:00 [pubmed]
PHST- 1981/07/01 00:01 [medline]
PHST- 1981/07/01 00:00 [entrez]
AID - 10.1152/ajpheart.1981.241.1.H95 [doi]
PST - ppublish
SO  - Am J Physiol. 1981 Jul;241(1):H95-103. doi: 10.1152/ajpheart.1981.241.1.H95.