PMID- 7248159
OWN - NLM
STAT- MEDLINE
DCOM- 19810922
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 43
IP  - 6
DP  - 1981 Jun
TI  - Value of serum calcitonin estimation in clinical oncology.
PG  - 786-92
AB  - In 132 consecutive patients with carcinoma of various organs, a higher serum 
      immunoreactive calcitonin (ICT) concentration (median level 50 pg/ml) was found 
      than in 68 normal subjects (median level 20 pg/ml). The incidence of 
      hypercalcitoninaemia was 40%. All 9 patients with primary liver-cell carcinoma 
      were hypercalcitoninaemic. On the other hand, none of the 7 patients with a 
      carcinoma of the breast had raised ICT levels. In bronchogenic cancer a 
      relationship between ICT and cell type was found, with a predominance of high ICT 
      in patients with oatcell and other undifferentiated types, whereas in 
      squamous-cell carcinomas and adenocarcinomas of the lung hypercalcitoninaemia was 
      relatively rare. When we divided all our patients according to differentiation of 
      the tumour cell, it was found that the lower the degree of differentiation, the 
      higher the ICT concentration, whereas opposite results were observed for CEA. 
      When ICT and CEA were estimated concurrently, we found at least one marker 
      increased in 70% of our patients. Our results demonstrate that patients with 
      metastases in the liver have more frequently and increased ICT. In addition, we 
      conclude that lifespan can be expected to be lower in patients with high ICT 
      levels. In a longitudinal study of 46 patients, there was a positive correlation 
      between change in serum ICT and tumour mass.
FAU - Mulder, H
AU  - Mulder H
FAU - Hackeng, W H
AU  - Hackeng WH
FAU - Silberbusch, J
AU  - Silberbusch J
FAU - den Ottolander, G J
AU  - den Ottolander GJ
FAU - van der Meer, C
AU  - van der Meer C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Carcinoembryonic Antigen)
RN  - 9007-12-9 (Calcitonin)
SB  - IM
MH  - Aged
MH  - Calcitonin/*blood
MH  - Carcinoembryonic Antigen/metabolism
MH  - Carcinoma, Bronchogenic/blood
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/blood/secondary
MH  - Lung Neoplasms/blood
MH  - Male
MH  - Neoplasms/*blood/therapy
MH  - Prognosis
PMC - PMC2010708
EDAT- 1981/06/01 00:00
MHDA- 1981/06/01 00:01
CRDT- 1981/06/01 00:00
PHST- 1981/06/01 00:00 [pubmed]
PHST- 1981/06/01 00:01 [medline]
PHST- 1981/06/01 00:00 [entrez]
AID - 10.1038/bjc.1981.116 [doi]
PST - ppublish
SO  - Br J Cancer. 1981 Jun;43(6):786-92. doi: 10.1038/bjc.1981.116.