PMID- 725548
OWN - NLM
STAT- MEDLINE
DCOM- 19790223
LR  - 20190902
IS  - 0036-5599 (Print)
IS  - 0036-5599 (Linking)
VI  - 12
IP  - 3
DP  - 1978
TI  - Platelet and fibrin(ogen) deposition in the artificial kidney. The influence of 
      haematocrit, fibrin monomer and platelet inhibitors. An in vitro study.
PG  - 259-64
AB  - The effect of variations in haematocrit (hct) on the retention of 51Cr-labelled 
      platelets and 125I-labelled fibrinogen from normal, heparinized, human blood, 
      circulated in an experimental "mini-Kiil" dialyzing system, was studied. Platelet 
      retention (PR) on dialysis membranes and blood lines was found to increase with 
      increasing hct. When only platelet rich plasma was circulated, a significantly 
      lower PR was noted on the blood lines. Fibrin(ogen) deposition on the same 
      surfaces showed a similar tendency. When 125I-labelled fibrin monomer was added 
      to normal blood, prior to dialysis, fibrin deposition on the membranes and blood 
      lines was of a much higher degree than in the control. However, PR was not 
      significantly influenced by the presence or deposition of the fibrin monomer. 
      Reduced platelet function, caused by incubation with acetylsalicylic acid prior 
      to dialysis, led to less PR on the blood lines, but not on the membranes. The 
      observed difference was, however, not statistically significant (p = 0.06). 
      Pretreatment of platelets with prostaglandin E1, however, was able to reduce PR 
      significantly both on dialysis membranes and blood lines.
FAU - Bjornson, J
AU  - Bjornson J
FAU - Brosstad, F
AU  - Brosstad F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Urol Nephrol
JT  - Scandinavian journal of urology and nephrology
JID - 0114501
RN  - 0 (Chromium Radioisotopes)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Prostaglandins E)
RN  - 9001-31-4 (Fibrin)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9005-49-6 (Heparin)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aspirin/*pharmacology
MH  - *Blood Platelets/drug effects
MH  - Chromium Radioisotopes
MH  - *Fibrin/analysis
MH  - *Fibrinogen/analysis
MH  - *Hematocrit
MH  - Heparin/pharmacology
MH  - Humans
MH  - Iodine Radioisotopes
MH  - *Kidneys, Artificial
MH  - Prostaglandins E/*pharmacology
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
AID - 10.3109/00365597809179727 [doi]
PST - ppublish
SO  - Scand J Urol Nephrol. 1978;12(3):259-64. doi: 10.3109/00365597809179727.