PMID- 7263132
OWN - NLM
STAT- MEDLINE
DCOM- 19811014
LR  - 20191031
IS  - 0091-2174 (Print)
IS  - 0091-2174 (Linking)
VI  - 11
IP  - 2
DP  - 1981-1982
TI  - Peaked "T" waves with tranylcypromine (parnate) overdose.
PG  - 155-60
AB  - A case of tranylcypromine (Parnate) overdose is presented in which the main toxic 
      effects were headache, obtundation, hypertension, and diffusely peaked T-waves on 
      ECG. The latter effect, which occurred in the absence of hyperkalemia, has not 
      been previously associated with monoamine oxidase inhibitors (MAOI). Recent case 
      reports of tranylcypromine toxicity are briefly reviewed, confirming the 
      potential for hypertension, hypotension, shock, hyperpyrexia, intracranial 
      hemorrhage, agitation, hyperkinesis, coma and death in association with 
      overdosage, or concomitant ingestion of sympathomimetic substances or other 
      drugs. These ECG changes add to the worrisome list of potential toxicities in an 
      era in which MAOI are finding increased clinical use.
FAU - Quill, T E
AU  - Quill TE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Int J Psychiatry Med
JT  - International journal of psychiatry in medicine
JID - 0365646
RN  - 3E3V44J4Z9 (Tranylcypromine)
SB  - IM
MH  - Adult
MH  - Depressive Disorder/drug therapy
MH  - *Electrocardiography
MH  - Female
MH  - Humans
MH  - Hypertension/chemically induced
MH  - Tranylcypromine/*poisoning/therapeutic use
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
AID - 10.2190/qa6e-7q65-5kwb-8pr2 [doi]
PST - ppublish
SO  - Int J Psychiatry Med. 1981-1982;11(2):155-60. doi: 10.2190/qa6e-7q65-5kwb-8pr2.