PMID- 7265321
OWN - NLM
STAT- MEDLINE
DCOM- 19811014
LR  - 20190909
IS  - 0388-1350 (Print)
IS  - 0388-1350 (Linking)
VI  - 5 Suppl
DP  - 1980 Dec
TI  - [Acute toxicity of lentinan in mice and rats (author's transl)].
PG  - 1-9
AB  - A new anti-tumor polysaccharide, lentinan (beta-1, 3 Glucan) was studied on the 
      acute toxicities using both sexes of mice (ICR) and rats (CD) treated by 
      intravenously (i.v.) intraperitoneally (i.p.), subcutaneously (s.c.) and orally 
      (p.o). LD50 values in mg/kg body weight were essentially the same regardless of 
      species as well as sexes and estimated as follows: 250-500 (i.v.) greater than 
      2500 (i.p., s.c., and p.o.). Cyanosis, convulsion and death were observed in both 
      species of animals administered (i.v.) with only higher dosages of lentinan. No 
      remarkable toxic signs being specific from lentinan were observed in any cases of 
      treatment, i.p., s.c., and p.o. Gross findings: enlargement of the spleen (i.v., 
      i.p., s.c.) and coarse nodular surface of the kidney (i.v.) in the both species 
      of animals, erythema of the ears (i.v., i.p., s.c.) in mice, mesenteric petechial 
      hemorrhage of the lung and abdomen (i.v.) enlargement of the mesenteric lymph 
      nodes (i.v.) and edema of the diaphragm and intestine (i.p.) in rats were 
      observed. In parallel, another sample of lentinan for clinical use prepared by 
      freeze-dried procedure was tested in both sexes of mice and rats treated by i.v. 
      alone, comparing with a original sample mentioned above. So far as the acute 
      toxicities of lentinans concerned, no significant differences between two 
      preparations were observed.
FAU - Moriyuki, H
AU  - Moriyuki H
FAU - Ichimura, M
AU  - Ichimura M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Polysaccharides)
RN  - 37339-90-5 (Lentinan)
SB  - IM
MH  - Animals
MH  - Female
MH  - Lentinan/administration & dosage/*toxicity
MH  - Lethal Dose 50
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Polysaccharides/*toxicity
MH  - Rats
EDAT- 1980/12/01 00:00
MHDA- 1980/12/01 00:01
CRDT- 1980/12/01 00:00
PHST- 1980/12/01 00:00 [pubmed]
PHST- 1980/12/01 00:01 [medline]
PHST- 1980/12/01 00:00 [entrez]
AID - 10.2131/jts.5.supplement_1 [doi]
PST - ppublish
SO  - J Toxicol Sci. 1980 Dec;5 Suppl:1-9. doi: 10.2131/jts.5.supplement_1.