PMID- 728685
OWN - NLM
STAT- MEDLINE
DCOM- 19790324
LR  - 20190509
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 64
IP  - 4
DP  - 1978 Dec
TI  - Responses of the simultaneously-perfused hepatic arterial and portal venous 
      vascular beds of the dog to histamine and 5-hydroxytryptamine.
PG  - 581-8
AB  - 1 The sympathetically-innervated hepatic arterial and portal venous vascular beds 
      of the dog were perfused simultaneously in situ. 2 Histamine and 
      5-hydroxytryptamine (5-HT) were injected intra-arterially and intraportally in 
      graded, increasing doses. 3 Intra-arterial histamine evoked decreases in hepatic 
      arterial vascular resistance (HAVR) and increases in hepatic portal vascular 
      resistance (HPVR). 4 Intraportal injections of histamine caused increases in HPVR 
      and decreases in HAVR. 5 The time courses of the arterial responses to 
      intraportal histamine and of the portal responses to intra-arterial histamine, 
      compared with any systemic effects, showed that these effects on the liver 
      vasculature could not be the result of recirculation of histamine. 6 
      Intra-arterial 5-HT evoked biphasic changes in HAVR and small falls in HPVR. 
      Intraportal 5-HT caused falls in HPVR at low doses and rises at high doses, 
      together, typically, with biphasic effects on HAVR. 7 It is unlikely that the 
      arterial effects of intraportal 5-HT and the portal effects of intra-arterial 
      5-HT were due to recirculation of the vasoactive material. 8 
      Pathophysiologically, both histamine and 5-HT are released from the 
      gastrointestinal tract into the portal vein. These experiments show that such 
      release may affect the hepatic arterial vascular resistance (and therefore blood 
      flow) even though vasoactive levels of the autacoids are not attained in the 
      systemic circulation.
FAU - Richardson, P D
AU  - Richardson PD
FAU - Withrington, P G
AU  - Withrington PG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 333DO1RDJY (Serotonin)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Dogs
MH  - Hemodynamics/drug effects
MH  - Hepatic Artery
MH  - Histamine/administration & dosage/*pharmacology
MH  - In Vitro Techniques
MH  - Injections, Intra-Arterial
MH  - Injections, Intravenous
MH  - Liver Circulation/*drug effects
MH  - Portal Vein
MH  - Serotonin/administration & dosage/*pharmacology
MH  - Time Factors
PMC - PMC1668453
EDAT- 1978/12/01 00:00
MHDA- 1978/12/01 00:01
PMCR- 1979/12/01
CRDT- 1978/12/01 00:00
PHST- 1978/12/01 00:00 [pubmed]
PHST- 1978/12/01 00:01 [medline]
PHST- 1978/12/01 00:00 [entrez]
PHST- 1979/12/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1978.tb17320.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1978 Dec;64(4):581-8. doi: 10.1111/j.1476-5381.1978.tb17320.x.