PMID- 7305888
OWN - NLM
STAT- MEDLINE
DCOM- 19820109
LR  - 20061115
IS  - 0006-2324 (Print)
IS  - 0006-2324 (Linking)
VI  - 24
IP  - 1-2
DP  - 1981 Jun
TI  - Temperature-sensitive alteration in fusion activity of subacute sclerosing 
      panencephalitis virus during serial passages in vitro and expression of 
      hemagglutinin on the infected cells.
PG  - 89-94
AB  - The Biken strain of subacute sclerosing panencephalitis (SSPE) virus, a 
      maturation-defective variant of measles virus, was serially passed in human 
      embryonic lung (HEL) cells at 37 C. The strain formed syncytial giant cells (GC) 
      at both 37 C and 39 C, but the surface of infected cells did not show 
      hemadsorption at early passages of the strain. However, GC-forming activity of 
      the strain diminished at 39 C after 25 passages or more and hemadsorption on the 
      infected cells became positive at both 37 C and 39 C after 40 passages or more of 
      the strain. Hardly any infectious cell-free virus was detected in the culture 
      fluid even after hemadsorption became positive. Possible mechanisms for the 
      defect of SSPE virus were discussed.
FAU - Ueda, S
AU  - Ueda S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biken J
JT  - Biken journal
JID - 0373117
RN  - 0 (Hemagglutinins, Viral)
SB  - IM
MH  - Cell Fusion
MH  - Cell Line
MH  - *Cytopathogenic Effect, Viral
MH  - *Hemadsorption
MH  - *Hemagglutinins, Viral
MH  - Humans
MH  - SSPE Virus/*physiology
MH  - Temperature
EDAT- 1981/06/01 00:00
MHDA- 1981/06/01 00:01
CRDT- 1981/06/01 00:00
PHST- 1981/06/01 00:00 [pubmed]
PHST- 1981/06/01 00:01 [medline]
PHST- 1981/06/01 00:00 [entrez]
PST - ppublish
SO  - Biken J. 1981 Jun;24(1-2):89-94.