PMID- 7353440
OWN - NLM
STAT- MEDLINE
DCOM- 19800417
LR  - 20191210
IS  - 0009-3157 (Print)
IS  - 0009-3157 (Linking)
VI  - 26
IP  - 1
DP  - 1980
TI  - Comparative efficacy of 5-methoxymethyl-2'-deoxyuridine, 9 
      beta-D-arabinofuranosyladenine and 5-iodo-2'-deoxyuridine in the treatment of 
      experimental herpes simplex keratitis.
PG  - 54-63
AB  - The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside 
      (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the 
      treatment of experimental herpes simplex keratitis was investigated in rabbits. 
      Treatment was initiated either at 4 or 24 h post virus inoculation. The parameter 
      used to evaluate effectiveness was lesion size. Each eye was graded daily for the 
      first 5 days and on alternate days thereafter to day 11. At concentrations of 2 
      or 5% both MMUdR and Ara-A were found to have potent antikeratitis activity. At 
      5% concentration, Ara-A provided essentially the same protection against herpes 
      keratitis as 0.1% IUdR, while MMUdR was slightly less effective. The simultaneous 
      application of 2% MMUdR and 2% Ara-A in combination was more effective than 5% 
      MMUdR alone and was effective as 5% Ara-A or 0.1% IUdR in controlling the viral 
      keratitis.
FAU - Meldrum, J B
AU  - Meldrum JB
FAU - Gupta, V S
AU  - Gupta VS
FAU - Babiuk, L A
AU  - Babiuk LA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Chemotherapy
JT  - Chemotherapy
JID - 0144731
RN  - 5116-22-3 (5-methoxymethyl-2'-deoxyuridine)
RN  - FA2DM6879K (Vidarabine)
RN  - LGP81V5245 (Idoxuridine)
RN  - W78I7AY22C (Deoxyuridine)
SB  - IM
MH  - Animals
MH  - Deoxyuridine/administration & dosage/*analogs & derivatives/therapeutic use
MH  - Drug Therapy, Combination
MH  - Female
MH  - Idoxuridine/administration & dosage/*therapeutic use
MH  - Keratitis, Dendritic/*drug therapy/pathology
MH  - Rabbits
MH  - Time Factors
MH  - Vidarabine/administration & dosage/*therapeutic use
EDAT- 1980/01/01 00:00
MHDA- 1980/01/01 00:01
CRDT- 1980/01/01 00:00
PHST- 1980/01/01 00:00 [pubmed]
PHST- 1980/01/01 00:01 [medline]
PHST- 1980/01/01 00:00 [entrez]
AID - 10.1159/000237883 [doi]
PST - ppublish
SO  - Chemotherapy. 1980;26(1):54-63. doi: 10.1159/000237883.