PMID- 7369372
OWN - NLM
STAT- MEDLINE
DCOM- 19800627
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 238
IP  - 3
DP  - 1980 Mar
TI  - Alterations in renal vascular resistance and reactivity in spontaneous 
      hypertension of rats.
PG  - H287-93
AB  - Vascular resistance and reactivity were investigated in isolated, constant flow 
      perfused kidneys of stroke-prone spontaneously hypertensive rats (SHRSP) and age- 
      and sex-matched normotensive Wistar-Kyoto control rats (WKY rats). Stroke-prone 
      spontaneously hypertensive rats were studied at 4 wk, 2 mo, and 4 mo of age 
      representing different stages of development of hypertension. Resistance in 
      maximally vasodilated vascular beds was greater and the pressure-flow 
      relationship was significantly shifted to the left in kidneys of SHRSP as 
      compared to WKY rats. Responses to norepinephrine, vasopressin, serotonin, and 
      angiotensin II were enhanced in the renal vascular bed of SHRSP. Dose-response 
      curves were shifted to the left, had steeper slopes, decreased thresholds, and 
      increased maximal responses. With longer duration of hypertension, resistance 
      increased, the slopes of the dose-response curves were steeper, and maximum 
      responses greater. The higher resistance and enhanced reactivity in the renal 
      vasculature of SHRSP, already demonstrable in the prehypertensive stage appear to 
      be due to primary structural and functional alterations of the resistance 
      vessels.
FAU - Berecek, K H
AU  - Berecek KH
FAU - Schwertschlag, U
AU  - Schwertschlag U
FAU - Gross, F
AU  - Gross F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 11000-17-2 (Vasopressins)
RN  - 11128-99-7 (Angiotensin II)
RN  - 333DO1RDJY (Serotonin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Aging
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Hypertension/genetics/*physiopathology
MH  - In Vitro Techniques
MH  - Kidney/*blood supply
MH  - Male
MH  - Muscle, Smooth, Vascular/physiopathology
MH  - Norepinephrine/pharmacology
MH  - Rats
MH  - Serotonin/pharmacology
MH  - Vascular Resistance/*drug effects
MH  - Vasopressins/pharmacology
EDAT- 1980/03/01 00:00
MHDA- 1980/03/01 00:01
CRDT- 1980/03/01 00:00
PHST- 1980/03/01 00:00 [pubmed]
PHST- 1980/03/01 00:01 [medline]
PHST- 1980/03/01 00:00 [entrez]
AID - 10.1152/ajpheart.1980.238.3.H287 [doi]
PST - ppublish
SO  - Am J Physiol. 1980 Mar;238(3):H287-93. doi: 10.1152/ajpheart.1980.238.3.H287.