PMID- 739219
OWN - NLM
STAT- MEDLINE
DCOM- 19790428
LR  - 20061115
IS  - 0146-4779 (Print)
IS  - 0146-4779 (Linking)
VI  - 2
IP  - 2
DP  - 1978 Nov-Dec
TI  - Hematologic changes in the rat during and after exposure to carbon monoxide.
PG  - 407-15
AB  - Rats were continuously exposed to 500 p.p.m. CO for 42 days. Hemoglobin 
      concentration, hematocrit ratio, and erythrocyte count increased rapidly, with 
      initial increases appearing after 4-7 days. Values of these parameters reached a 
      plateau after 25-30 days of exposure 50 percent, 44 percent, and 42 percent above 
      controls, respectively. Reticulocyte count peaked 600 percent above controls 7-10 
      days after initial exposure. This was reflected in the blood indices, mean 
      corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), 
      and mean corpuscular volume (MCV). MCHC fell 6 percent by the fifth day of 
      exposure, while MCH and MCV increased 11 percent and 16 percent respectively, by 
      the seventh day. MCHC returned to control by the thirteenth day, while MCH and 
      MCV remained elevated until the twenty-fifth day of CO exposure. During "stable" 
      polycythemia both MCHC and MCH were depressed, while MCV was slightly elevated 
      above the controls. Platelet count declined substantially within 20-25 days of 
      exposure. Hb, Hct ratio and RBC count fell to control values in the time interval 
      between 10 and 30 days post exposure. This was accompanied by transient fall in 
      reticulocyte count from 2.5 percent (control value) to 0.1-0,2 percent between 
      the twelfth and twenty-sixth day after exposure. Platelet count returned to the 
      control value when polycythemia had subsided.
FAU - Penney, D G
AU  - Penney DG
FAU - Bishop, P A
AU  - Bishop PA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Environ Pathol Toxicol
JT  - Journal of environmental pathology and toxicology
JID - 7801245
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Animals
MH  - Blood Cell Count
MH  - Blood Platelets/drug effects
MH  - Carbon Monoxide Poisoning/*blood
MH  - Erythrocyte Count
MH  - Hemoglobins/metabolism
MH  - Leukocyte Count
MH  - Male
MH  - Rats
MH  - Reticulocytes/drug effects
MH  - Time Factors
EDAT- 1978/11/01 00:00
MHDA- 1978/11/01 00:01
CRDT- 1978/11/01 00:00
PHST- 1978/11/01 00:00 [pubmed]
PHST- 1978/11/01 00:01 [medline]
PHST- 1978/11/01 00:00 [entrez]
PST - ppublish
SO  - J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):407-15.