PMID- 7408956
OWN - NLM
STAT- MEDLINE
DCOM- 19801125
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 66
IP  - 1
DP  - 1980 Aug 22
TI  - Age-related hypotensive effect of atropine in unanesthetized spontaneously 
      hypertensive rats.
PG  - 103-9
AB  - Intravenous injection of atropine (0.5-20 mg/kg) produced a dose- and 
      age-dependent decrease in the mean arterial pressure (MAP) of conscious 
      spontaneously hypertensive (SH) rats 11-20 weeks of age. No effect on blood 
      pressure occurred in age-matched Wistar-Kyoto (WKY) controls; however, heart rate 
      was increased in both groups. In contrast to atropine, the same doses of 
      methylatropine increased MAP and heart rate in both SH and WKY rats. 
      Methylatropine also failed to modify the hypotensive effect of atropine in SH 
      rats. The difference between the effects on blood pressure of atropine and 
      methylatropine in SH rats was not seen when the animals were anesthetized with 
      pentobarbital. In this case both agents reduced MAP. Intracerebroventricular 
      (i.c.v.) injection of atropine in doses up to 200 microgram in SH rats failed to 
      modify MAP and was without effect on the hypotensive response to intravenous 
      injection of atropine. Likewise, i.c.v. injection of hemicholinium-3 (which 
      reduces MAP in SH rats) failed to modify the hypotensive effect of atropine. 
      However, intravenous injection of atropine (10 mg/kg) prevented the hypotensive 
      effect of hemicholinium-3. Thee results are discussed in terms of central and 
      peripheral muscarinic mechanisms.
FAU - Caputi, A P
AU  - Caputi AP
FAU - Camilleri, B H
AU  - Camilleri BH
FAU - Brezenoff, H E
AU  - Brezenoff HE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 312-45-8 (Hemicholinium 3)
RN  - 7C0697DR9I (Atropine)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Atropine/administration & dosage/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Heart Rate/drug effects
MH  - Hemicholinium 3/pharmacology
MH  - Hypertension/*physiopathology
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Rats
EDAT- 1980/08/22 00:00
MHDA- 1980/08/22 00:01
CRDT- 1980/08/22 00:00
PHST- 1980/08/22 00:00 [pubmed]
PHST- 1980/08/22 00:01 [medline]
PHST- 1980/08/22 00:00 [entrez]
AID - 0014-2999(80)90300-3 [pii]
AID - 10.1016/0014-2999(80)90300-3 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1980 Aug 22;66(1):103-9. doi: 10.1016/0014-2999(80)90300-3.