PMID- 7414085
OWN - NLM
STAT- MEDLINE
DCOM- 19801125
LR  - 20131121
IS  - 0034-5288 (Print)
IS  - 0034-5288 (Linking)
VI  - 28
IP  - 3
DP  - 1980 May
TI  - Glutathione peroxidase activity in bovine serum and erythrocytes in relation to 
      selenium concentrations of blood, serum and liver.
PG  - 321-4
AB  - The concentration of selenium (Se) in liver, serum and whole blood, and the 
      activity of glutathione peroxidase (GSH-px) in serum and erythrocytes were 
      monitored for seven months after the administration of Se to Se-deficient calves. 
      There was a rapid increase in Se concentration in liver and serum, followed by an 
      exponential decline with half-lives of 22.1 +/- 0.2 days and 28.3 +/- 2.0 days 
      respectively. Whole blood Se concentration also increased rapidly but declined 
      more slowly than liver or serum Se concentraations. The rise in Se concentration 
      and GSH-px activity in erythrocytes was delayed and both levels remained elevated 
      several months after liver and serum Se concentrations had become marginal or 
      deficient. GSH-px activity in serum increased more rapidly after dosing and 
      declined more rapidly than GSH-px activity in erythrocytes. The results suggest 
      that liver and serum Se concentration and serum GSH-px activity respond to 
      changes in dietary Se intake more rapidly than either whole blood Se or 
      erythrocyte GSH-px activity. Two-monthly administrations of Se, at the current 
      recommended therapeutic dose (0.1 mg Se/kg as sodium selenate) appears to be 
      necessary to maintain adequate Se levels in calves on Se-deficient pasture.
FAU - Thompson, K G
AU  - Thompson KG
FAU - Fraser, A J
AU  - Fraser AJ
FAU - Harrop, B M
AU  - Harrop BM
FAU - Kirk, J A
AU  - Kirk JA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - EC 1.11.1.- (Peroxidases)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Cattle/blood/*metabolism
MH  - Cattle Diseases/blood
MH  - Erythrocytes/*enzymology
MH  - Glutathione Peroxidase/*blood
MH  - Liver/*metabolism
MH  - Peroxidases/*blood
MH  - Selenium/blood/deficiency/*metabolism
EDAT- 1980/05/01 00:00
MHDA- 1980/05/01 00:01
CRDT- 1980/05/01 00:00
PHST- 1980/05/01 00:00 [pubmed]
PHST- 1980/05/01 00:01 [medline]
PHST- 1980/05/01 00:00 [entrez]
PST - ppublish
SO  - Res Vet Sci. 1980 May;28(3):321-4.