PMID- 7417615
OWN - NLM
STAT- MEDLINE
DCOM- 19801216
LR  - 20131121
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 15
IP  - 2
DP  - 1980 Apr
TI  - Drug modification of ECT: methohexital and diazepam. II.
PG  - 257-64
AB  - A systematic comparison of methohexital and diazepam as anesthetics in the drug 
      modification of ECT was done by holding atropinizaton, 
      succinylcholine-depolarizing neuromuscular blockade, and resuscitation constant 
      while monitoring four ECT in each of 24 patients. Each patient served as his own 
      control, and two dosages of each drug (0.25 and 0.35 mg/kg diazepam, 0.9 and 1.1 
      mg/kg methohexital) were given each patient in all possible orderings (4! = 24) 
      in a scheduled experimental design in which methohexital was given by very rapid 
      (5 sec) and diazepam was given by the recommended slower (60 sec) infusion. The 
      data revealed significant differences and methohexital was superior. Eight of 48 
      (17%) EKGs were abnormal post-ECT with methohexital, 18 of 48 (38%, phi = 5.3, p 
      < 0.025) with diazepam. Five of 24 (21%) patients had an abnormal post-ECT EKG 
      with methohexital, 15 of 24 (60%, phi 8.6, p < 0.005) with diazepam. 
      Significantly more ventricular premature contractions (VPCs) occurred after 
      diazepam. Diazepam records contained both more numerous and more extensive EKG 
      abnormalities. Methohexital induction was clinically superior as well; there was 
      little of the induction restlessness seen in seven treatments with diazepam (phi2 
      7.6, p < 0.01). The differences were less marked than in a previous study in 
      which diazepam was given as rapidly as methohexital. Methohexital has been 
      demonstrated to be the anexthesia of safety and choice for ECT when compared to 
      diazepam.
FAU - Allen, R E
AU  - Allen RE
FAU - Pitts, F N Jr
AU  - Pitts FN Jr
FAU - Summers, W K
AU  - Summers WK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - E5B8ND5IPE (Methohexital)
RN  - Q3JTX2Q7TU (Diazepam)
SB  - IM
MH  - Diazepam/administration & dosage/*pharmacology
MH  - Drug Evaluation
MH  - *Electroconvulsive Therapy
MH  - Heart/drug effects
MH  - Humans
MH  - Injections, Intravenous
MH  - Methohexital/administration & dosage/*pharmacology
EDAT- 1980/04/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1980/04/01 00:00
PHST- 1980/04/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1980/04/01 00:00 [entrez]
PST - ppublish
SO  - Biol Psychiatry. 1980 Apr;15(2):257-64.